55154-30-8 Usage
Description
AH 7921, also known as an opioid, is an analytical reference material and an analgesic with high addictive liability in animal models. It is regulated as a Schedule I compound in the United States and is intended for research and forensic applications.
Uses
Used in Research Applications:
AH 7921 is used as a research compound for studying the effects and mechanisms of opioids on the central nervous system. Its high addictive liability in animal models makes it a valuable tool for understanding opioid addiction and developing potential treatments or interventions.
Used in Forensic Applications:
AH 7921 is used as a forensic compound in the identification and analysis of controlled substances, particularly in cases involving drug-related crimes or overdose incidents. Its classification as a Schedule I compound in the United States further emphasizes its importance in forensic investigations.
Used in Pharmaceutical Development:
Although AH 7921 itself is not approved for medical use due to its high addictive potential, it may serve as a starting point for the development of new, less addictive analgesics. Researchers can study its structure and activity to design safer and more effective pain-relieving medications.
Used in Regulatory Compliance:
AH 7921 is used as a reference material in the development and validation of testing methods for the detection and quantification of opioids in various samples, such as blood, urine, or tissue. This helps ensure the accuracy and reliability of drug testing procedures and supports regulatory compliance in the pharmaceutical industry and law enforcement agencies.
Check Digit Verification of cas no
The CAS Registry Mumber 55154-30-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,1,5 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 55154-30:
(7*5)+(6*5)+(5*1)+(4*5)+(3*4)+(2*3)+(1*0)=108
108 % 10 = 8
So 55154-30-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H22Cl2N2O/c1-20(2)16(8-4-3-5-9-16)11-19-15(21)12-6-7-13(17)14(18)10-12/h6-7,10H,3-5,8-9,11H2,1-2H3,(H,19,21)
55154-30-8Relevant articles and documents
Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with 18F-Labeled Derivatives in Rats
Ott, Julian,Spilhaug, Mona M.,Maschauer, Simone,Rafique, Waqas,Jakobsson, Jimmy E.,Hartvig, Karoline,Hübner, Harald,Gmeiner, Peter,Prante, Olaf,Riss, Patrick J.
, p. 9484 - 9499 (2020)
The 3,4-dichloro-N-(1-(dimethylamino)cyclohexyl)methyl benzamide scaffold was studied as a template for 18F-positron emission tomography (18F-PET) radiotracer development emphasizing sensitivity to changes in opioid receptor (OR) occupancy over high affinity. Agonist potency, binding affinity, and relevant pharmacological parameters of 15 candidates were investigated. Two promising compounds 3b and 3e with μ-OR (MOR) selective agonist activity in the moderate range (EC50 = 1-100 nM) were subjected to 18F-fluorination, autoradiography, and small-animal PET imaging. Radioligands [18F]3b and [18F]3e were obtained in activity yields of 21 ± 5 and 23 ± 4% and molar activities of 25-40 and 200-300 GBq/μmol, respectively. Displaceable binding matching MOR distribution in the brain was confirmed by imaging. Radioligands showed a rapid pharmacokinetic profile; however, metabolite-corrected, blood-based modeling was required for data analysis. Observed BPND was low, although treatment with naloxone leads to a marked decrease in specific binding, confirming the discovery of a new template for 18F-labeled OR-agonist PET ligands.
AH-7921 DETECTION
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Paragraph 0072; 0073, (2016/09/26)
Antibodies, immunoassay methods and kits for the detection and determination of 3,4,-dichloro-N-[(1-(dimethylamino)cyclohexyl)methyl]benzamide and 3,4,-dichloro-N-[(1-(methylamino)cyclohexyl)methyl]benzamide, as well as the precursory immunogens, are described.
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