55154-71-7

Basic information

• Product Name: N-(2-{[2-(diethylamino)ethyl]amino}-5-nitrophenyl)-2-(4-ethoxyphenyl)acetamide
• CAS NO: 55154-71-7
• Molecular Formula: C₂₂H₃₀N₄O₄
• Molecular Weight: 414.498
• Mol File: 55154-71-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 618.8°C at 760 mmHg
• Flash Point: 328°C
• Density: 1.202g/cm³
• Vapor Pressure: 3.08E-15mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: N-(2-{[2-(diethylamino)ethyl]amino}-5-nitrophenyl)-2-(4-ethoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-{[2-(diethylamino)ethyl]amino}-5-nitrophenyl)-2-(4-ethoxyphenyl)acetamide(55154-71-7)
• EPA Substance Registry System: N-(2-{[2-(diethylamino)ethyl]amino}-5-nitrophenyl)-2-(4-ethoxyphenyl)acetamide(55154-71-7)

Safety Data

• Hazardous Substances Data: 55154-71-7(Hazardous Substances Data)

Upstream product

• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 100-36-7 N,N-diethylethylenediamine 
• 56223-91-7 N’-(2,4-dinitrophenyl)-N,N-diethylethane-1,2-diamine 
• 4919-33-9 4-ethoxyphenylacetic acid 
• 5099-39-8 N⁽¹⁾-(2-(diethylamino)ethyl)-4-nitrobenzene-1,2-diamine 

Downstream Products

• 911-65-9 etonitazene 
• 925216-79-1 2-(4-ethoxybenzyl)-1-(1-methylpiperidin-4-yl)-5-nitro-1H-benzo[d]imidazole 
• 925216-51-9 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)thiophen-2-carboximidamide 
• 925216-80-4 N-(2-(4-ethoxybenzyl)-1-(1-methylpiperidin-4-yl)-1H-benzo[d]imidazol-5-yl)thiophen-2-carboximidamide 
• 925216-58-6 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)furan-2-carboximidamide 
• 925216-65-5 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)thiophen-3-carboximidamide 
• 925216-60-0 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)furan-3-carboximidamide 
• 925216-54-2 N-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)acetimidamide 
• 925216-62-2 1-(1-(2-(diethylamino)ethyl)-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-yl)-3-nitroguanidine 
• 75821-80-6 1-[2-(diethylamino)ethyl]-2-(4-ethoxybenzyl)-1H-benzo[d]imidazol-5-amine 

Relevant articles and documents

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NOpiates: Novel dual action neuronal nitric oxide synthase inhibitors with μ-opioid agonist activity

A novel series of benzimidazole designed multiple ligands (DMLs) with activity at the neuronal nitric oxide synthase (nNOS) enzyme and the μ-opioid receptor was developed. Targeting of the structurally dissimilar heme-containing enzyme and the μ-opioid GPCR was predicated on the modulatory role of nitric oxide on μ-opioid receptor function. Structure-activity relationship studies yielded lead compound 24 with excellent nNOS inhibitory activity (IC50 = 0.44 μM), selectivity over both endothelial nitric oxide synthase (10-fold) and inducible nitric oxide synthase (125-fold), and potent μ-opioid binding affinity, Ki = 5.4 nM. The functional activity as measured in the cyclic adenosine monosphospate secondary messenger assay resulted in full agonist activity (EC50 = 0.34 μM). This work represents a novel approach in the development of new analgesics for the treatment of pain.