5516-83-6

Basic information

• Product Name: 5,5a,6,7,8,9-hexahydro-11H-pyrido<2,1-b>quinazoline
• Synonyms: 5,5a,6,7,8,9-hexahydro-11H-pyrido<2,1-b>quinazoline
• CAS NO: 5516-83-6
• Molecular Weight: 188.272
• Mol File: 5516-83-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,5a,6,7,8,9-hexahydro-11H-pyrido<2,1-b>quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5a,6,7,8,9-hexahydro-11H-pyrido<2,1-b>quinazoline(5516-83-6)
• EPA Substance Registry System: 5,5a,6,7,8,9-hexahydro-11H-pyrido<2,1-b>quinazoline(5516-83-6)

Safety Data

• Hazardous Substances Data: 5516-83-6(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 552-89-6 2-nitro-benzaldehyde 
• 2446-62-0 7,8,9-trihydropyrido[2,1-b]quinazolin-11(6H)-one 

Downstream Products

• 2446-62-0 7,8,9-trihydropyrido[2,1-b]quinazolin-11(6H)-one 

Relevant articles and documents

Redox Condensations of o-Nitrobenzaldehydes with Amines under Mild Conditions: Total Synthesis of the Vasicinone Family

A total synthesis of the vasicinone family of natural products from bulk chemicals was developed. Reductive condensation of o-nitrobenzaldehydes with amines utilizing iron pentacarbonyl as a reducing agent followed by subsequent oxidation leads to a great variety of polycyclic nitrogen-containing heterocycles under mild conditions. Enantiomerically pure vasicinone, rutaecarpine, isaindigotone, and luotonin were synthesized from readily available starting materials like hydroxyproline, nitrobenzaldehyde, pyrrolidine, and piperidine in two to four operational steps without chromatography. The antifungal activity of all products was tested.