55175-50-3

Basic information

• Product Name: ethyl 1H-benzimidazol-1-ylacetate
• Synonyms: 1H-benzimidazole-1-acetic acid, ethyl ester
• CAS NO: 55175-50-3
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.2252
• Mol File: 55175-50-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 344.3°C at 760 mmHg
• Flash Point: 162°C
• Density: 1.19g/cm³
• Vapor Pressure: 6.64E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: ethyl 1H-benzimidazol-1-ylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1H-benzimidazol-1-ylacetate(55175-50-3)
• EPA Substance Registry System: ethyl 1H-benzimidazol-1-ylacetate(55175-50-3)

Safety Data

• Hazardous Substances Data: 55175-50-3(Hazardous Substances Data)

Upstream product

• 51-17-2 benzoimidazole 
• 105-39-5 chloroacetic acid ethyl ester 
• 95-54-5 1,2-diamino-benzene 
• 105-36-2 ethyl bromoacetate 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 54980-92-6 2-(benzimidazol-1-yl)acetamide 
• 40332-16-9 2-(1H-benzo[d]imidazol-1-yl)acetic acid 
• 791806-33-2 C₁₀H₁₀N₆S 
• 332157-78-5 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-phenylacetamide 
• 332128-58-2 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-chlorophenyl)acetamide 
• 332157-84-3 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-bromophenyl)acetamide 
• 1382131-93-2 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-fluorophenyl)acetamide 
• 1382131-95-4 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-iodophenyl)acetamide 
• 332157-79-6 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-nitrophenyl)acetamide 
• 1382131-98-7 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-cyanophenyl)acetamide 
• 332870-17-4 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-p-tolylacetamide 
• 552814-05-8 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-methoxyphenyl)acetamide 
• 1382132-03-7 2-(5-((1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazol-2-ylthio)-N-(4-ethoxyphenyl)acetamide 
• 157198-80-6 Benzoimidazol-1-yl-acetyl chloride 

Relevant articles and documents

Analgesic and anti-inflammatory activity of new analogs of HC-030031: A TRPA1 channel antagonist

One of our study direction is research in the group of compounds affecting the TRPA1 ion channel (Transient receptor potential cation channel, subfamily A, member 1) which can perform an important function in pain (including neuropathic pain) and inflamma

Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl) acetamides as antibacterial, antifungal and antituberculosis agents

To affiliate multiple bioactivities in a compact heteronuclei, two series of benzimidazole based 1,3,4-oxadiazoles were synthesized and assessed in vitro for their efficacy as antimicrobial agents against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella flexneri), four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus clavatus, Candida albicans) and Mycobacterium tuberculosis H37Rv and best results were observed amongst the N-benzothiazolyl aetamide series. The lipophilicity (LogP) influence on the biological profile (MICs) of the prepared products was also discussed. Upon biological screening, it was observed that the majority of the compounds were found to possess a significant broad spectrum antimicrobial (3.12-25 μg/mL of MIC) and antitubercular (6.25-25 μg/mL of MIC) potential. The structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR spectroscopy and elemental analysis.

Solid-liquid phase alkylation of n-heterocycles: Microwave-assisted synthesis as an environmentally friendly alternative

The solid-liquid phase alkylation of a variety of five-membered N-heterocycles (carbazole, imidazole, benzimidazole, and indole-3-carbaldehyde) was carried out under different conditions. The use of alkali carbonate in dimethylformamide or in MeCN (in the latter case, in the presence of a phase-transfer catalyst) is a suitable method to prepare the corresponding N-alkylated products in an efficient way. In most cases, the solventless, microwave-assisted reaction is an environmentally friendly alternative to traditional methods. Copyrigh