551944-18-4

Basic information

• Product Name: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
• Synonyms: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
• CAS NO: 551944-18-4
• Molecular Weight: 364.485
• Mol File: 551944-18-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(551944-18-4)
• EPA Substance Registry System: (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid(551944-18-4)

Safety Data

• Hazardous Substances Data: 551944-18-4(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 858519-32-1 (1S,4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid methoxymethyl ester 
• 5947-49-9 podocarpic acid 
• 4614-56-6 methyl podocarpate 
• 55025-16-6 methyl (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate 
• 858519-33-2 (1S,4aS,10aR)-6-Benzyloxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid methoxymethyl ester 

Downstream Products

• 551943-96-5 (4β,5α)-12-Hydroxy-N-[(1-phenylcyclobutyl)methyl]podocarpa-8,11,13-trien-16-amide 
• 551944-24-2 (4β,5α)-12-(Benzyloxy)-N-{[1-(3-methoxyphenyl)cyclohexyl]methyl}podocarpa-8,11,13-trien-16-amide 
• 551944-29-7 (1S,4aS,10aR)-6-(benzyloxy)-N-((1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carbonyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide 
• 551944-28-6 (1S,4aS,10aR)-6-(benzyloxy)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxamide 
• 551944-35-5 1,3-Bis-((1S,4aS,10aR)-6-benzyloxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-propane-1,3-dione 
• 551944-26-4 (4β,5α)-12-(Benzyloxy)podocarpa-8,11,13-trien-16-yl (4β,5α)-12-(benzyloxy)podocarpa-8,11,13-trien-16-oate 
• 551944-27-5 C₄₈H₅₄O₅ 

Relevant articles and documents

ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF

Provided herein are antibodies and antigen-binding fragments that bind MSR1 and methods of use thereof. According to certain embodiments, the antibodies bind human MSR1 with high affinity. In certain embodiments, the antibodies bind MSR1 without blocking, or blocking less than 90%, of modified LDL binding to MSR1. In some embodiments, the antibodies bind cell surface expressed-MSR1 and are internalized. The antibodies of the invention may be fully human antibodies. The invention includes anti-MSR1 antibodies, or antigen-binding fragments thereof, conjugated to drugs or therapeutic compounds.

CYCLODEXTRIN PROTEIN DRUG CONJUGATES

Provided herein are compounds, compositions, conjugates and methods for the treatment of diseases, and/or conditions such as, but not limited to, proliferative diseases. In certain embodiments, compounds, compositions, and conjugates are provided, which include cyclodextrin-based linker-payloads and protein conjugates thereof, and/or in combination with other agents. By administering these compounds, compositions, and conjugates as described herein to specific target cells, side-effects due to non-specific binding phenomena, for example, to non-target cells are reduced.

Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters

Liver X receptors are nuclear receptors that regulate metabolism of cholesterol. They are activated by oxysterols resulting in increased transcription of the ABCA1 gene, promoting cholesterol efflux and HDL formation. We have identified podocarpic acid an