55208-76-9Relevant articles and documents
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Sanderson et al.
, p. 2239,2240 (1975)
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Synthesis and antimalarial activities of novel 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes
Zmitek, Katja,Stavber, Stojan,Zupan, Marko,Bonnet-Delpon, Daniele,Charneau, Sebastien,Grellier, Phillipe,Iskra, Jernej
, p. 7790 - 7795 (2007/10/03)
The oxidative system H2O2/fluorinated alcohol (TFE, HFIP) was used for direct acid- and MeReO3-catalyzed synthesis of 1,2,4,5-tetraoxanes from cyclic (C6, C7, and C12) and acyclic ketones. The influence of ring size and alkyl chain length were studied and antimalarial activities of synthetic 3,3,6,6-tetraalkyl-1,2,4,5-tetraoxanes were determined. Variations in their antimalarial activities were significant, although they share similar electrochemical properties of the peroxide bond.