55210-79-2Relevant articles and documents
An efficient transformation of primary halides into nitriles through palladium-catalyzed hydrogen transfer reaction
Zou, Tao,Yu, Xiaoqiang,Feng, Xiujuan,Bao, Ming
, p. 10714 - 10717 (2015)
Two-step one-pot transformation of primary halides into corresponding nitriles is successfully achieved. Nucleophilic substitution of primary halides with sodium azide and subsequent palladium-catalyzed hydrogen transfer proceeds smoothly in the presence of sterically bulky ligand dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (XPhos) in acetone to produce nitriles in satisfactory to good yields. This journal is