55218-73-0

Basic information

• Product Name: 2-Hydroxymethyl-4-phenylpyridine
• Synonyms: 2-Hydroxymethyl-4-phenylpyridine;(4-Phenylpyridin-2-yl)Methanol
• CAS NO: 55218-73-0
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22184
• Mol File: 55218-73-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-Hydroxymethyl-4-phenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxymethyl-4-phenylpyridine(55218-73-0)
• EPA Substance Registry System: 2-Hydroxymethyl-4-phenylpyridine(55218-73-0)

Safety Data

• Hazardous Substances Data: 55218-73-0(Hazardous Substances Data)

Usage

General Description

2-Hydroxymethyl-4-phenylpyridine, also known as HPPH, is a chemical compound with the molecular formula C12H11NO. It is an organic compound consisting of a pyridine ring with a hydroxymethyl and phenyl substituent. HPPH has been studied for its potential use in photodynamic therapy for the treatment of cancer, as it has shown promising photosensitizing properties. It has also been investigated for its potential anti-inflammatory and antioxidant properties. HPPH has the potential to be a valuable tool in medical research and the development of new treatments for various diseases.

Upstream product

• 55218-70-7 4-Phenyl-2-picolin-1-oxid 
• 15032-21-0 2-methyl-4-phenylpyridine 
• 18714-17-5 methyl 4-phenylpyridine-2-carboylate 
• 67-56-1 methanol 
• 98-80-6 phenylboronic acid 
• 22282-99-1 4-bromo-2-methylpyridine 

Downstream Products

• 55218-76-3 4-phenyl-2-pyridinaldehyde 
• 83782-51-8 2-<<(p-bromophenyl)thio>methyl>-4-phenylpyridine 

Relevant articles and documents

Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms

Considering the synthetic relevance of heteroarenes in various areas ranging from organic synthesis to medicinal chemistry, developing practically simple methodologies to access functionalized heteroarenes is of a significant value. Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation. The synthetic importance of the developed reactions is demonstrated by the synthesis of biologically relevant compounds. Electron paramagnetic resonance spectroscopy, quantum yield measurements, and density-functional theory calculations allowed us to understand reaction mechanisms of both photocatalytic reactions.

SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease.