5526-61-4

Basic information

• Product Name: 3-[(5E)-5-(2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)propanamide
• CAS NO: 5526-61-4
• Molecular Formula: C₁₇H₁₂O₂S
• Molecular Weight: 420.5289
• Mol File: 5526-61-4.mol
• Article Data: 4

Chemical Properties

• Density: 1.5g/cm³
• Refractive Index: 1.709
• CAS DataBase Reference: 3-[(5E)-5-(2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(5E)-5-(2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)propanamide(5526-61-4)
• EPA Substance Registry System: 3-[(5E)-5-(2-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)propanamide(5526-61-4)

Safety Data

• Hazardous Substances Data: 5526-61-4(Hazardous Substances Data)

Upstream product

• 90-11-9 1-Bromonaphthalene 
• 147-93-3 Thiosalicylic acid 
• 529-36-2 1-Naphthalenethiol 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 613670-88-5 1-(2-bromomethyl-phenylsulfanyl)-naphthalene 
• 56057-01-3 [2-(naphthalene-1-ylsulfanyl)-phenyl]-methanol 
• 95854-95-8 2-(Naphthalene-1-sulfonyl)-benzoic acid 
• 131073-64-8 2-(Naphthalene-1-sulfinyl)-benzoic acid 
• 3604-44-2 Benzothioxanthon 
• 56165-46-9 2/1-Naphthyl(thio)benzylchlorid 
• 56057-03-5 [2-(naphthalene-1-ylsulfanyl)phenyl]acetic acid 
• 56057-02-4 [2-(naphthalene-1-ylsulfanyl)-phenyl]-acetonitrile 

Relevant articles and documents

Development of Potent Type i Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation

Protein Arginine Methyltransferases (PRMTs) are crucial players in diverse biological processes, and dysregulation of PRMTs has been linked to various human diseases, especially cancer. Therefore, small molecules targeting PRMTs have profound impact for both academic functional studies and clinical disease treatment. Here, we report the discovery of N1-(2-((2-chlorophenyl)thio)benzyl)-N1-methylethane-1,2-diamine (28d, DCPR049-12), a highly potent inhibitor of type I PRMTs that has good selectivity against a panel of other methyltransferases. Compound 28d effectively inhibits cell proliferation in several leukemia cell lines and reduces the cellular asymmetric arginine dimethylation levels. Serving as an effective inhibitor, 28d demonstrates the mechanism of cell killing in both cell cycle arrest and apoptotic effect as well as downregulation of the pivotal mixed lineage leukemia (MLL) fusion target genes such as HOXA9 and MEIS1, which reflects the critical roles of type I PRMTs in MLL leukemia. These studies present 28d as a valuable inhibitor to investigate the role of type I PRMTs in cancer and other diseases.

1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF

The present invention relates to 1- or 3-thiabenzonaphthoazulene derivatives to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to t