5528-53-0

Basic information

• Product Name: N-[(E)-(4,8-dimethoxynaphthalen-1-yl)methylidene]-1-(prop-2-en-1-yl)-1H-benzimidazol-2-amine
• CAS NO: 5528-53-0
• Molecular Formula: C₁₀H₇N₃S
• Molecular Weight: 371.4317
• Mol File: 5528-53-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 580.372°C at 760 mmHg
• Flash Point: 304.799°C
• Density: 1.164g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: N-[(E)-(4,8-dimethoxynaphthalen-1-yl)methylidene]-1-(prop-2-en-1-yl)-1H-benzimidazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(E)-(4,8-dimethoxynaphthalen-1-yl)methylidene]-1-(prop-2-en-1-yl)-1H-benzimidazol-2-amine(5528-53-0)
• EPA Substance Registry System: N-[(E)-(4,8-dimethoxynaphthalen-1-yl)methylidene]-1-(prop-2-en-1-yl)-1H-benzimidazol-2-amine(5528-53-0)

Safety Data

• Hazardous Substances Data: 5528-53-0(Hazardous Substances Data)

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 527-72-0 2-thiophenylcarboxylic acid 
• 4075-59-6 2-thiopheneglyoxylic acid 
• 98-03-3 thiophene-2-carbaldehyde 
• 3437-95-4 2-Iodothiophene 
• 274-80-6 [1,2,4]triazolo[4,3-a]pyridine 
• 85957-46-6 N-pyridin-2-yl-N'-thiophen-2-ylmethylene-hydrazine 

Relevant articles and documents

KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: Efficient one-pot synthesis of 1,2,4-triazolo[4,3-a] pyridines

A one-pot approach to substituted 1,2,4-triazolo[4,3-a]pyridines has been developed that is based on a KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines. This transition-metal-free procedure was highly efficient and shows good economical and environmental advantages.

A Convenient One-Pot Synthesis of Triazolopyridine and Related Heterocycle Fused-Triazole Analogs Through Copper Catalyzed Oxidative Cyclization Strategy

One-pot synthesis of heterocycle fused-triazole analogs from the corresponding aldehydes and heteroarylhydrazines is demonstrated. Transformation of hydrazones to the desired systems was achieved by employing the oxidative cyclization with catalytic CuBr2 and oxone. This reaction condition is mild and selective, and a wide range of functional groups were able to sustain. An array of biologically important triazolopyridines, triazolopyridazines, triazolopyrimidines, and triazoloquinolines were obtained in fairly good yield.

An environmentally benign and solvent-free synthesis of 3-aryl[1,2,4]triazolo[4,3-a]pyridines and 1-aryl-5-methyl[1,2,4]triazolo[4,3-a] quinolines using phenyliodine bis(trifluoroacetate) or iodobenzene diacetate

A simple, solvent-free and effective method for oxidative cyclization of 2-pyridyl- and 2-quinolylhydrazones with phenyliodine bis(trifluoroacetate) and iodobenzene diacetate to the corresponding 3-aryl[1,2,4]triazolo[4,3-a]pyridines and 1-aryl[1,2,4]tria