55294-15-0 Usage
Description
Muzolimine, also known by the brand name EDRUL, is a structurally novel pyrazolone diuretic with a high-ceiling profile. It is characterized by its slower onset compared to furosemide but offers a more prolonged effect, similar to thiazides. Muzolimine has demonstrated effectiveness in treating edema of cardiac, hepatic, and renal origin and has also shown potential as an antihypertensive agent.
Uses
Used in Pharmaceutical Industry:
Muzolimine is used as a diuretic for its ability to treat edema of cardiac, hepatic, and renal origin. Its effectiveness in these areas makes it a valuable asset in managing fluid retention and related conditions.
Additionally, Muzolimine is used as an antihypertensive agent for its potential to help manage high blood pressure. Its prolonged effect and slower onset make it a suitable option for patients requiring long-lasting blood pressure control.
Originator
Bayer (W. Germany)
Manufacturing Process
41 g of α-methyl-3,4-dichlorobenzylhydrazine, dissolved in absolute ethanol,
were added dropwise to a solution of 31.8 g of β-amino-β-ethoxyacrylic acid
ethyl ester and 1.5 g of p-toluenesulfonic acid in 150 ml of ethanol at room
temperature under nitrogen gas. After stirring for 2 hours and standing
overnight, the reaction solution was concentrated as far as possible on a
rotary evaporator. The residue which remained was dissolved in 2 N sodium
hydroxide solution. Any unconverted starting products or by-products were
extracted with ether. The aqueous phase was then brought to pH 5 with acetic
acid. The oil thereby produced was taken up in methylene chloride and the
organic phase was dried over Na2SO4. After evaporating off the solvent, the
reaction product crystallized out. It was recrystallized from methanol; melting
point 127°C to 129°C; yield 21 g (38.5% of theory).
Therapeutic Function
Diuretic
World Health Organization (WHO)
Reports of neurological adverse effects, including paraesthesiae
and paralyses, associated with prolonged use of high dosages of muzolimine, were
received shortly after its introduction in 1984.
Check Digit Verification of cas no
The CAS Registry Mumber 55294-15-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,2,9 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 55294-15:
(7*5)+(6*5)+(5*2)+(4*9)+(3*4)+(2*1)+(1*5)=130
130 % 10 = 0
So 55294-15-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)