55304-75-1

Basic information

• Product Name: 2,6-Dichloro-3-(trifluoromethyl)pyridine
• Synonyms: 2,6-Dichloro-3-(trifluoromethyl)pyridine,97%;2,6-Dichloro-alpha,alpha,alpha-trifluoro-3-picoline;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDINE, PURISS, 98%;2,6-DICHLORO-3-(TRIFLUOROMETHYL)PYRIDIN&;2,6-Dichloro-3-[trifluoromethy;2,6-DICHLORO-3-[TRIFLUOROMETHYL]-PYRIDINE 99+%
• CAS NO: 55304-75-1
• Molecular Formula: C₆H₂Cl₂F₃N
• Molecular Weight: 215.99
• EINECS: 259-585-8
• Product Categories: Fluorine series;Pyridine;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridines
• Mol File: 55304-75-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 194 °C
• Boiling Point: 194-196 °C(lit.)
• Flash Point: 218 °F
• Appearance: /
• Density: 2.008 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.162mmHg at 25°C
• Refractive Index: n20/D 1.4850(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -4.84±0.10(Predicted)
• BRN: 1570287
• CAS DataBase Reference: 2,6-Dichloro-3-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-3-(trifluoromethyl)pyridine(55304-75-1)
• EPA Substance Registry System: 2,6-Dichloro-3-(trifluoromethyl)pyridine(55304-75-1)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 26-36/37-45
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 55304-75-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C6H2Cl2F3N/c7-4-2-1-3(5(8)12-4)6(9,10)11/h1-2H

Upstream product

• 55366-30-8 2,6-dichloro-3-(trichloromethyl)pyridine 
• 7783-56-4 antimony(III) fluoride 
• 87-69-4 tartaric acid 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 108-99-6 3-Methylpyridine 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 148493-37-2 2,6-dichloro-3-iodo-pyridine 
• 261956-65-4 2-chloro-5-trifluoromethylpyridine 1-oxide 

Downstream Products

• 683243-59-6 (6-chloro-5-trifluoromethyl-pyridin-2-yl)-(4-methoxy-benzyl)-amine, trifluoroacetic acid salt 
• 1076234-34-8 1-{[6-chloro-5-(trifluoromethyl)(2-pyridyl)]amino}-3,4-di-methylazoline-2,5-dione 
• 1076234-45-1 3,4-dimethyl-1-{[6-phenyl-5-(trifluoromethyl)(2-pyridyl)]amino}azoline-2,5-dione 
• 7631-86-9 SiO₂ 
• 1426922-08-8 6-Chloro-2-(4-tert-butylphenyl)-3-(trifluoromethyl) pyridine 
• 1426922-07-7 6-chloro-2-(4-ethoxyphenyl)-3-(trifluoromethyl)pyridine 
• 1426922-19-1 C₂₂H₂₀F₃N 
• 1426922-06-6 6-Chloro-2-(4-ethylphenyl)-3-(trifluoromethyl) pyridine 
• 1426922-05-5 6-Chloro-2-(3,5-dimethylphenyl)-3-(trifluoromethyl)pyridine 
• 1261782-78-8 2,6-Bis(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)-pyridine 
• 1426922-04-4 6-Chloro-2-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl) pyridine 
• 1426922-16-8 2,6-Di(4-acetylphenyl)-3-(trifluoromethyl) pyridine 
• 1426922-03-3 6-Chloro-2-(4-acetylphenyl)-3-(trifluoromethyl) pyridine 
• 1426922-15-7 2,6-Di-p-tolyl-3-(trifluoromethyl)pyridine 

Relevant articles and documents

SUBSTITUTED AZOLE DIONE COMPOUNDS WITH ANTIVIRAL ACTIVITY

Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.

METHOD FOR SEPARATING AND PURIFYING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE

A method for separating and purifying 2-chloro-3-trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like is provided. The method includes: 1) in the process of producing chloro β-trifluoromethylpyridine compounds by allowing a β-methylpyridine compound to react with chlorine and hydrogen fluoride in a reaction apparatus, allowing a β-trifluoromethylpyridine compound to react with chlorine in a reaction apparatus, or allowing a chloro β-trichloromethylpyridine compound to react with hydrogen fluoride in a reaction apparatus,2) fractionating a liquid mixture containing chloro β-trifluoromethylpyridine compounds from the reaction apparatus, and3) separating and purifying 2-chloro-3-trifluoromethylpyridine from the liquid mixture.

Compounds with anti-cancer activity

Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.