55305-43-6 Usage
Description
N-Cyano-N-phenyl-p-toluenesulfonamide, also known as N-phenyltoluenesulfonamide cyanide, is an organic compound that serves as an important intermediate in the synthesis of various chemical compounds. It is characterized by its cyano and phenyl groups attached to a toluenesulfonamide moiety, which contributes to its reactivity and utility in chemical reactions.
Uses
Used in Chemical Synthesis:
N-Cyano-N-phenyl-p-toluenesulfonamide is used as a research reactant for the synthesis of 1,2,4-triazol-3-imines through stepwise cycloaddition. This application is significant in the development of new chemical compounds with potential applications in various fields, such as pharmaceuticals, materials science, and agrochemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Cyano-N-phenyl-p-toluenesulfonamide is used as a key intermediate in the synthesis of various drug candidates. Its unique chemical structure allows for the creation of novel molecules with potential therapeutic properties, contributing to the advancement of drug discovery and development.
Used in Materials Science:
N-Cyano-N-phenyl-p-toluenesulfonamide is also utilized in the field of materials science for the development of new materials with specific properties. Its reactivity and functional groups enable the synthesis of compounds that can be used in the creation of advanced materials for various applications, such as electronics, coatings, and adhesives.
Check Digit Verification of cas no
The CAS Registry Mumber 55305-43-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,3,0 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55305-43:
(7*5)+(6*5)+(5*3)+(4*0)+(3*5)+(2*4)+(1*3)=106
106 % 10 = 6
So 55305-43-6 is a valid CAS Registry Number.
55305-43-6Relevant articles and documents
Rhodium(III)-catalyzed cyanation of vinylic C-H bonds: N-cyano-N-phenyl-p-toluenesulfonamide as a cyanation reagent
Su, Wei,Gong, Tian-Jun,Xiao, Bin,Fu, Yao
, p. 11848 - 11851 (2015)
Rh(iii)-catalyzed direct vinylic C-H cyanation reaction has been developed as a practical method for the synthesis of alkenyl nitriles. N-Cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS), a user-friendly cyanation reagent, was used in the transformation.
COMPOUNDS TARGETING PRMT5
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Paragraph 0306, (2021/10/11)
Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
Ni-Catalyzed Reductive Arylcyanation of Alkenes
Li, Hengxu,Chen, Jiachang,Dong, Jueqi,Kong, Wangqing
supporting information, p. 6466 - 6470 (2021/08/23)
We disclose a Ni-catalyzed reductive arylcyanation of alkene using environmentally benign and nontoxic organo cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide. This reaction provides a new method for the rapid synthesis of cyano-substituted oxindoles and isoquinoline-1,3-diones and features high functional group tolerance. In addition, an enantioselective version was developed for the construction of enantiomerically enriched 3-cyanomethyl oxindole. This method has also been applied to the synthesis of natural alkaloids (+)-esermethole and (+)-physostigmine.
