5534-13-4 Usage
Description
9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate, also known as Betamethasone propionate, is a synthetic glucocorticoid derived from the natural hormone cortisol. It is a white to off-white solid with potent anti-inflammatory and immunosuppressive properties, making it a valuable compound in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate is used as a glucocorticoid for its potent anti-inflammatory and immunosuppressive effects. It is particularly effective in treating various inflammatory and autoimmune conditions, such as rheumatoid arthritis, asthma, and allergies.
Used in Dermatological Applications:
In the dermatological field, 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate is used as a topical treatment for various skin conditions, including eczema, psoriasis, and contact dermatitis. Its anti-inflammatory and immunosuppressive properties help to reduce redness, swelling, and itching associated with these conditions.
Used in Ophthalmic Applications:
9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate is also used in ophthalmology as an anti-inflammatory agent for treating eye conditions such as uveitis, iritis, and postoperative inflammation following ocular surgery.
Used in Veterinary Medicine:
In veterinary medicine, 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate is used as a glucocorticoid to treat inflammatory and immune-mediated conditions in animals, similar to its applications in human medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 5534-13-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,5,3 and 4 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5534-13:
(6*5)+(5*5)+(4*3)+(3*4)+(2*1)+(1*3)=84
84 % 10 = 4
So 5534-13-4 is a valid CAS Registry Number.
InChI:InChI=1/C25H33FO6/c1-5-21(31)32-25(20(30)13-27)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,26)19(29)12-23(18,25)4/h8-9,11,14,17-19,27,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1
5534-13-4Relevant articles and documents
Preparation method of betamethasone 17 alpha-propionate
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, (2019/08/20)
The invention provides a preparation method of betamethasone 17 alpha-propionate. According to the preparation method, betamethasone is subjected to a reaction with triethyl orthopropionate, the reaction is performed in a tetrahydrofuran solvent, further, p-toluenesulfonic acid is adopted as a catalyst, after the reaction is finished, an aluminum trichloride solution is dropwise added to the samesolvent system directly without discharging, a thermal insulation reaction is performed after the solution is dropwise added, and betamethasone 17 alpha-propionate is obtained with a post-treatment process. According to the preparation method of betamethasone 17 alpha-propionate, preparation process is simplified, yield is increased and purity is improved while the problem that dioxane, dimethylformamide or another solvent is adopted as the reaction solvent of betamethasone 17 alpha-propionate is solved.
Composition for the topical treatment of poison ivy and other forms of contact dermatitis
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, (2008/06/13)
Composition for topical administration comprising (a) a corticosteroid, and (b) a drying agent.
An improved synthesis of corticosteroid 17α-esters by synthetic aluminium silicate-mediated conversion of 17α, 21-cyclic ortho esters
Sugai,Okazaki,Akaboshi
, p. 700 - 701 (2007/10/02)
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