55368-37-1

Basic information

• Product Name: 4,4'-(2,5-Furandiyl)bis-benzonitrile
• Synonyms: 4,4'-(2,5-Furandiyl)bis-benzonitrile
• CAS NO: 55368-37-1
• Molecular Formula: C₁₈H₁₀N₂O
• Molecular Weight: 270.2848
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 55368-37-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
• CAS DataBase Reference: 4,4'-(2,5-Furandiyl)bis-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-(2,5-Furandiyl)bis-benzonitrile(55368-37-1)
• EPA Substance Registry System: 4,4'-(2,5-Furandiyl)bis-benzonitrile(55368-37-1)

Safety Data

• Hazardous Substances Data: 55368-37-1(Hazardous Substances Data)

Usage

Description

4,4'-(2,5-Furandiyl)bis-benzonitrile is an organic compound characterized by its brown solid appearance. It is known for its potential applications in various industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
4,4'-(2,5-Furandiyl)bis-benzonitrile is used as a key component in the preparation of antimicrobial agents. Its application is particularly focused on the treatment of Pneumocystis carinii infections, which are significant concerns in the field of medicine.
Chemical Properties:
As a brown solid, 4,4'-(2,5-Furandiyl)bis-benzonitrile exhibits distinct chemical properties that make it suitable for use in the development of antimicrobial agents. Its structure and composition contribute to its effectiveness in targeting and treating specific infections, such as those caused by Pneumocystis carinii.

Upstream product

• 20099-89-2 4-Cyanophenacyl bromide 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 110-00-9 furan 
• 623-00-7 4-bromobenzenecarbonitrile 
• 63366-23-4 2,5-bis(trimethylstannyl)furan 
• 611-13-2 2-furoic acid methyl ester 
• 88-14-2 2-furanoic acid 

Downstream Products

• 166601-11-2 4,4’-(furan-2,5-diyl)bis(N-(3-(dimethylamino)propyl)benzimidamide) 
• 214216-23-6 2,5-bis(4-formylphenyl)furan 
• 194298-15-2 2,5-bis(4-carboxyphenyl)furan 
• 236098-07-0 C₂₂H₂₂N₂O₃ 
• 61829-76-3 2,5-bis<4-(4,5-dihydro-1H-imidazol-2-yl)phenyl>furan dihydrochloride 
• 80498-75-5 1,1'-dimethyl-1,4,5,6,1',4',5',6'-octahydro-2,2'-(4,4'-furan-2,5-diyl-diphenyl)-bis-pyrimidine 
• 61829-78-5 1,3,1',3'-tetramethyl-4,5,4',5'-tetrahydro-3H,3'H-tetrahydro-2,2'-(4,4'-furan-2,5-diyl-diphenyl)-bis-imidazolium; dichloride 
• 80498-72-2 1,1'-dimethyl-4,5,4',5'-tetrahydro-1H,1'H-2,2'-(4,4'-furan-2,5-diyl-diphenyl)-bis-imidazole 
• 65356-05-0 1,3,1',3'-tetramethyl-3,4,5,6,3',4',5',6'-octahydro-2,2'-(4,4'-furan-2,5-diyl-diphenyl)-bis-pyrimidinium; dihydrochloride 
• 80498-74-4 DB 103 
• 80498-71-1 DB 60 

Relevant articles and documents

Hexafluoroisopropanol as solvent and promotor in the Paal-Knorr synthesis of N-substituted diaryl pyrroles

An additive-free synthesis of challenging N-substituted aryl pyrroles from the often poorly soluble corresponding 1,4-diketones by means of the Paal-Knorr pyrrole synthesis is reported, which makes use of the unique properties of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as a solvent and reaction promotor. Our procedure offers simple execution and purification as well as easy scale-up and can be applied in the Paal-Knorr synthesis of a large number of structurally diverse pyrroles including the synthetically challenging tetra- and penta-substituted pyrroles in moderate to excellent yields. HFIP can also be used as solvent in the Paal-Knorr synthesis of furans and thiophenes; however, the solvent effect is more pronounced in synthesis of pyrroles.

Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold

Structural studies of the 3′-end of the oncogenic long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) confirmed a unique triple-helix structure. This structure enables accumulation of the transcript, and high levels of MALAT1 are found in several cancers. Here, we synthesize a small molecule library based on an RNA-binding scaffold, diphenylfuran (DPF), screen it against a variety of nucleic acid constructs, and demonstrate for the first time that the MALAT1 triple helix can be selectively targeted with small molecules. Computational analysis revealed a trend between subunit positioning and composition on DPF shape and intramolecular interactions, which in turn generally correlated with selectivity and binding strengths. This work thus provides design strategies toward chemical probe development for the MALAT1 triple helix and suggests that comprehensive analyses of RNA-focused libraries can generate insights into selective RNA recognition.

Synthesis and?evaluation of?cytotoxic activity of?arylfurans

A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells.