55449-46-2 Usage
Description
((R)-2-CHLORO-PROPYL)-BENZENE, with the molecular formula C9H11Cl, is a chemical compound that features a benzene ring with a propyl group attached to it, and a chlorine atom attached to the propyl group. This chiral compound is known for its specific stereochemistry, with the R-configuration indicating the arrangement of atoms in three-dimensional space.
Uses
Used in Organic Synthesis:
((R)-2-CHLORO-PROPYL)-BENZENE is used as a building block in organic synthesis for the production of various other chemicals. Its unique structure allows it to be a versatile intermediate in the creation of a wide range of compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, ((R)-2-CHLORO-PROPYL)-BENZENE is used as an intermediate for the synthesis of various drugs. Its specific stereochemistry can be crucial in the development of enantiomerically pure pharmaceuticals, which can have different biological activities and effects.
Used in Agrochemical Development:
((R)-2-CHLORO-PROPYL)-BENZENE also finds application in the agrochemical sector, where it serves as an intermediate in the synthesis of pesticides, herbicides, and other agricultural chemicals. Its role in these processes can contribute to the development of more effective and targeted agrochemicals.
Used in Fine Chemicals Industry:
((R)-2-CHLORO-PROPYL)-BENZENE is utilized in the production of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors. The quality and specificity of ((R)-2-CHLORO-PROPYL)-BENZENE make it suitable for such applications.
Used in Research and Development:
In the field of organic chemistry, ((R)-2-CHLORO-PROPYL)-BENZENE is used in research and development for studying reaction mechanisms, exploring new synthetic routes, and developing innovative chemical processes.
Used in Specialty Materials Production:
((R)-2-CHLORO-PROPYL)-BENZENE may have potential uses in the industry for the production of specialty materials, where its unique properties can be leveraged to create new materials with specific characteristics for various applications.
Used as a Solvent:
In some cases, ((R)-2-CHLORO-PROPYL)-BENZENE may also be used as a solvent in industrial processes, although its use in this capacity would depend on its solubility properties and the specific requirements of the process.
Check Digit Verification of cas no
The CAS Registry Mumber 55449-46-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,4 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 55449-46:
(7*5)+(6*5)+(5*4)+(4*4)+(3*9)+(2*4)+(1*6)=142
142 % 10 = 2
So 55449-46-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H11Cl/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3/t8-/m1/s1
55449-46-2Relevant articles and documents
CaF2 catalyzed SN2 type chlorodehydroxylation of chiral secondary alcohols with thionyl chloride: A practical and convenient approach for the preparation of optically active chloroalkanes
Zhang, Junjie,Wang, Huanxia,Ma, Yun,Wang, Youming,Zhou, Zhenghong,Tang, Chuchi
, p. 2261 - 2263 (2013/05/09)
A CaF2 catalyzed chlorodehydroxylation of chiral secondary alcohols with thionyl chloride has been developed. The chlorination reaction is effective for a wide range of alcohols, generating the corresponding chloroalkanes in good yield with high optical purity with inversion of the original configuration of the alcohol.
Chlorination of aliphatic primary alcohols via triphosgene-triethylamine activation
Ayala, Caitlan E.,Villalpando, Andres,Nguyen, Alex L.,McCandless, Gregory T.,Kartika, Rendy
supporting information; experimental part, p. 3676 - 3679 (2012/09/08)
Activation of primary aliphatic alcohols with triphosgene and triethylamine mixtures afforded either alkyl chloride or diethylcarbamate products, and the switch in selectivity appeared to be driven by sterics. The reaction conditions to achieve this highly useful transformation were unexceptionally mild and readily tolerated by a wide range of sensitive functionalities.
Retentive Friedel-Crafts Alkylation of Benzene with Optically Active 2-Chloro-1-phenylpropane and 1-Chloro-2-phenylpropane
Masuda, Shinji,Nakajima, Tadashi,Suga, Sohei
, p. 1089 - 1094 (2007/10/02)
Alkylations of benzene with both (-)-2-chloro-1-phenylpropane (1) and (+)-1-chloro-2-phenylpropane (2) in the presence of Lewis acid gave the same products: (-)-1,2-diphenylpropane (3), 1,1-diphenylpropane, and polymeric materials. In these reactions, (-)-3 was obtained in 45-100percent optical yield and was not racemized under the conditions used. These results reveal that the reaction from 1 to 3 proceeds with retention of configuration and that from 2 to 3 with inversion. The stereochemistry of the alkylation with 1 is elucidated by the mechanism involving a neighboring phenyl ?-assisted cation; benzene attacks only the β-carbon of 1 from the side on which the previously attached chloride anion is located. The result of the reaction with 2 can be explained by a process involving the 1,2-shift of phenyl group in the ionization step of 2, followed by the formation of the same intermediate as in the reaction with 1. The mechanism of the overall reaction is discussed.
