55482-27-4 Usage
Description
Biliverdin dihydrochloride (BV) is a near-infrared (NIR)-absorbing pigment that is endogenously produced as a linear tetrapyrrolic intermediate during the heme degradation process, specifically the conversion of heme to bilirubin. It is primarily found in the bile of amphibians and birds, where it is the dominant pigment instead of bilirubin.
Uses
Used in Pharmaceutical Applications:
Biliverdin dihydrochloride is used as a cytoprotective agent, playing a crucial role in protecting cells from various types of damage. It is particularly effective in the context of organ transplantation, as it has been shown to induce tolerance to cardiac allografts, thereby reducing the risk of organ rejection.
Additionally, Biliverdin dihydrochloride is used as a regulator in the cellular heme degradation process. It occupies the heme binding site on heme oxygenase, which prevents the access of the substrate to the catalytic site of the enzyme. This regulation can have significant implications for various medical applications, particularly those involving the management of heme-related conditions.
Used in Diagnostic Imaging:
Due to its near-infrared (NIR) absorption properties, Biliverdin dihydrochloride can be utilized in diagnostic imaging techniques, such as fluorescence imaging, to enhance the visualization of specific biological processes or structures in vivo. Its unique optical properties make it a valuable tool for researchers and clinicians in the field of medical imaging.
Used in Drug Delivery Systems:
Similar to Gallotannin, Biliverdin dihydrochloride can also be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the delivery, efficacy, and overall performance of Biliverdin dihydrochloride can be enhanced, making it a more effective treatment option for various medical conditions.
Biochem/physiol Actions
Biliverdin (BV) is an excellent anti-inflammatory agent that protects against lipopolysaccharides (LPS)-induced lung injury in mouse endothelial cells. It aids protection in polymicrobial sepsis. Biliverdin has cytoprotective effects on rat livers and protects from prolonged ischemia and reperfusion injury. It also shows antioxidant activities.
Check Digit Verification of cas no
The CAS Registry Mumber 55482-27-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,4,8 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 55482-27:
(7*5)+(6*5)+(5*4)+(4*8)+(3*2)+(2*2)+(1*7)=134
134 % 10 = 4
So 55482-27-4 is a valid CAS Registry Number.
InChI:InChI=1/C33H34N4O6.2ClH/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26;;/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41);2*1H/b26-13-,27-14-,28-15-;;
