55486-27-6

Basic information

• Product Name: 1-CINNAMOYL-PIPERAZINE
• Synonyms: RARECHEM AH CK 0075;1-[(2E)-3-PHENYLPROP-2-ENOYL]PIPERAZINE;1-CINNAMOYL-PIPERAZINE;1-CINNAMOYL-PIPERAZINE >96%;1-(3-Phenylacryloyl)piperazine, 1-Cinnamoylpiperazine;3-Phenyl-1-(piperazin-1-yl)prop-2-en-1-one
• CAS NO: 55486-27-6
• Molecular Formula: C₁₃H₁₆N₂O
• Molecular Weight: 216.28
• Product Categories: piperazines
• Mol File: 55486-27-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 420.5 °C at 760 mmHg
• Flash Point: 208.1 °C
• Appearance: /
• Density: 1.116 g/cm³
• Vapor Pressure: 2.8E-07mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 1-CINNAMOYL-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CINNAMOYL-PIPERAZINE(55486-27-6)
• EPA Substance Registry System: 1-CINNAMOYL-PIPERAZINE(55486-27-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 55486-27-6(Hazardous Substances Data)

Usage

General Description

1-Cinnamoyl-piperazine is a chemical compound that consists of a piperazine ring with a cinnamoyl (phenylacryloyl) group attached to it. It is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, such as antipsychotics and antidepressants. 1-CINNAMOYL-PIPERAZINE has been found to exhibit anti-inflammatory, analgesic, and central nervous system effects, making it a potential candidate for the development of new therapeutic agents. Additionally, 1-Cinnamoyl-piperazine has been studied for its potential role in the treatment of neurological disorders, and it shows promise as a neuroprotective agent. Its diverse pharmacological properties make it a valuable and versatile compound in drug discovery and development.

InChI:InChI=1/C13H16N2O/c16-13(15-10-8-14-9-11-15)7-6-12-4-2-1-3-5-12/h1-7,14H,8-11H2/b7-6+

Upstream product

• 110-85-0 piperazine 
• 102-92-1 cinnamoyl chloride 
• 621-82-9 Cinnamic acid 
• 7542-23-6 piperazine hydrochloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 84050-18-0 4-amino-2-(4-cinnamoylpiperazino)-6,7-dimethoxyquinazoline hydrochloride 

Relevant articles and documents

In quest of small-molecules as potent non-competitive inhibitors against influenza

A series of scaffolds namely aurones, 3-indolinones, 4-quinolones and cinnamic acid-piperazine hybrids, was designed, synthesized and investigated in vitro against influenza A/H1N1pdm09 virus. Designed molecules adopted different binding mode i.e., in 430-cavity of neuraminidase, unlike sialic acid and oseltamivir in molecular docking studies. All molecules reduced the viral titer and exhibited non-cytotoxicity along with cryo-protective property towards MDCK cells. Molecules (Z)-2-(3′-Chloro-benzylidene)-1,2-dihydro-indol-3-one (2f), (Z)-2-(4′-Chloro-benzylidene)-1,2-dihydro-indol-3-one (2g) and 2-(2′-Methoxy-phenyl)-1H-quinolin-4-one (3a) were the most interesting molecules identified in this research, endowed with robust potencies showing low-nanomolar EC50 values of 4.0 nM, 6.7 nM and 4.9 nM, respectively, compared to reference competitive and non-competitive inhibitors: oseltamivir (EC50 = 12.7 nM) and quercetin (EC50 = 0.56 μM), respectively. Besides, 2f, 2g and 3a exhibited good neuraminidase inhibitory activity in sub-micromolar range (IC50 = 0.52 μM, 3.5 μM, 1.3 μM respectively). Moreover, these molecules were determined as non-competitive inhibitors similar to reference non-competitive inhibitor quercetin unlike reference competitive inhibitor oseltamivir in kinetics studies.

1 - (cinnamoyl) - 4-piperidyl amide piperazine compound and its preparation method

The invention discloses a 1-(cinnamoyl)-4-piperidyl amide piperazidine compound and a preparation method thereof. The 1-(cinnamoyl)-4-piperidyl amide piperazidine compound is a compound shown as the formula (I) and pharmaceutically acceptable salt. The co

Preparing method of N-monosubstituted piperazine compound

The invention discloses a preparing method of an N-monosubstituted piperazine compound shown in the formula (6). Piperazine monohydrochloride (1) and RX or RCl react in solvent to prepare monosubstituted piperazine dihydrochloride (4) or (5), alkali is added for neutralizing, and the product (6) is obtained through rectification steaming.