55487-93-9

Basic information

• Product Name: 4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE
• Synonyms: 4-METHYLUMBELLIFERYL-B-D-FUCOSIDE;4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE;4-METHYLUMBELLIFERYL BETA-D-FUCOSIDE;4-MU-BETA-D-FUC;METHYLUMBELLIFERYL-B-D-FUCOPYRANOSIDE, 4-;7-[(6-deoxy-beta-D-galactopyranosyl)oxy]-4-methyl-2H-1-benzopyran-2-one;4-methylumbelliferyl β-d-fucopyranoside;4-methylumbelliferyl β-d-fucoside
• CAS NO: 55487-93-9
• Molecular Formula: C16H18O7
• Molecular Weight: 322.31
• EINECS: 259-666-8
• Product Categories: Substrates
• Mol File: 55487-93-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 565.9oC at 760 mmHg
• Flash Point: 211.3oC
• Appearance: /
• Density: 1.441g/cm3
• Vapor Pressure: 1.21E-13mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: −20°C
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• Stability: Hygroscopic
• CAS DataBase Reference: 4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE(55487-93-9)
• EPA Substance Registry System: 4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE(55487-93-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 55487-93-9(Hazardous Substances Data)

Usage

Description

4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE, also known as 4-MU-Fuc, is a synthetic compound that serves as a fluorogenic substrate. It is widely utilized in the detection and measurement of β-D-Fucosidase enzyme activity. 4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE, when cleaved by the enzyme, produces a blue fluorescent solution, making it an essential tool in various research and diagnostic applications.

Uses

Used in Research Applications:
4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE is used as a research tool for the detection and quantification of β-D-Fucosidase enzyme activity. The reason for its application is that it provides a sensitive and reliable method to measure the enzyme's activity, which is crucial in understanding the enzyme's role in various biological processes.
Used in Diagnostic Applications:
In the field of diagnostics, 4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE is used as a diagnostic marker for certain diseases and conditions. The application reason is that the enzyme β-D-Fucosidase is involved in the metabolism of various substances, and its abnormal activity can be indicative of specific health issues. By measuring the enzyme's activity using this substrate, medical professionals can gain valuable insights into a patient's condition and guide appropriate treatment.
Used in Pharmaceutical Industry:
4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE is used as a quality control agent in the pharmaceutical industry for the assessment of β-D-Fucosidase inhibitors. The application reason is that these inhibitors can be potential therapeutic agents for treating diseases associated with abnormal β-D-Fucosidase activity. By using this substrate, researchers can evaluate the effectiveness of these inhibitors and optimize their development for clinical use.
Used in Biotechnology Applications:
In the biotechnology industry, 4-METHYLUMBELLIFERYL-BETA-D-FUCOPYRANOSIDE is used as a substrate for the development of biosensors and high-throughput screening assays. The application reason is that the blue fluorescent signal produced upon enzyme cleavage allows for the rapid and accurate detection of β-D-Fucosidase activity, which can be integrated into various biotechnological applications, such as drug discovery and enzyme engineering.

InChI:InChI=1/C16H18O7/c1-7-5-12(17)23-11-6-9(3-4-10(7)11)22-16-15(20)14(19)13(18)8(2)21-16/h3-6,8,13-16,18-20H,1-2H3/t8-,13+,14+,15-,16+/m1/s1

Upstream product

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Relevant articles and documents

CARBONIC ANHYDRASE INHIBITORS WITH ANTIMETASTATIC ACTIVITY

Compositions for the treatment of cancer comprising coumarin and thiocoumarin derivatives of Formulas I- XII are disclosed. Said derivatives preferentially inhibit carbonic anhydrase IX and XII (which are associated with hypoxic and metastatic tumours) over inhibiting carbonic anhydrase I and II activity. The compositions therefore are suited for treatment of hypoxic or metastatic cancers due to this selective mechanism of action.

Profiling of glycosidase activities using coumarin-conjugated glycoside cocktails

Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.