5554-54-1

Basic information

• Product Name: 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97
• Synonyms: 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97;1,2,2,6,6-Pentamethylpiperidin-4-one;1,2,2,6,6-Pentamethyl-4-piperidone;1,2,2,6,6-Pentamethyl-4-piperidone 97%
• CAS NO: 5554-54-1
• Molecular Formula: C₁₀H₁₉NO
• Molecular Weight: 169.266
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Piperidones
• Mol File: 5554-54-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 230-231 °C(lit.)
• Flash Point: 195 °F
• Appearance: /
• Density: 0.949 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: n20/D 1.476(lit.)
• Storage Temp.: ?20°C
• CAS DataBase Reference: 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97(5554-54-1)
• EPA Substance Registry System: 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97(5554-54-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 5554-54-1(Hazardous Substances Data)

Usage

Description

1,2,2,6,6-Pentamethyl-4-piperidone, also known as 97, is an organic compound that serves as an intermediate in the synthesis of pentamethylpiperidines, which hold significant pharmacological importance. 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97 has been studied for its conformational properties through various analytical methods, including proton magnetic resonance spectra, dipole moments, and molar Kerr constant.

Uses

1. Used in Pharmaceutical Industry:
1,2,2,6,6-Pentamethyl-4-piperidone 97 is used as a chemical intermediate for the preparation of pentamethylpiperidines, which are compounds with potential pharmacological applications. The synthesis of these compounds is crucial for developing new drugs and therapies in the pharmaceutical industry.
2. Used in Chemical Synthesis:
1,2,2,6,6-Pentamethyl-4-piperidone 97 is used as a key component in the preparation of specific piperidine derivatives, such as 1-phenyl-2,2,6,6-tetramethyl-4-phenyliminopiperidine and 1-benzyl-2,2,6,6-tetramethyl-4-benzyliminopiperidine. These derivatives have potential applications in various fields, including the development of new materials and chemical products.

InChI:InChI=1/C10H19NO/c1-9(2)6-8(12)7-10(3,4)11(9)5/h6-7H2,1-5H3

Upstream product

• 504-20-1 phorone 
• 74-89-5 methylamine 
• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 
• 616-38-6 carbonic acid dimethyl ester 
• 77-78-1 dimethyl sulfate 
• 2403-89-6 1,2,2,6,6-pentamethyl-piperidin-4-ol 
• 67-64-1 acetone 
• 50-00-0 formaldehyd 
• 74-88-4 methyl iodide 

Downstream Products

• 17107-09-4 1,2,2,6,6-pentamethyl-4-phenyl-piperidin-4-ol 
• 92884-76-9 3,5-dimethylidene-1,2,2,6,6-pentamethyl-4-oxopiperidine 
• 133828-20-3 1,2,2,6,6-pentamethyl-3-methylene-4-piperidone 
• 75620-69-8 1,2,2,4,6,6-hexamethyl-4-piperidinol 
• 113308-50-2 1,2,2,6,6-pentamethyl-4-piperidone methiodide 
• 20430-62-0 1.2.2.7.7-pentamethylhexahydro-1.4-diazepin-5-one 
• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 
• 133828-13-4 1,2,2,3,6,6-hexamethyl-4-piperidone 
• 133828-14-5 1,2,2,3,3,6,6-heptamethyl-4-piperidone 
• 134614-22-5 r-1,2,2,c-3,6,6-heptamethyl-c-4-piperidol 
• 134614-27-0 r-1,2,2,c-3,c-4,6,6-heptamethyl-4-piperidol 
• 134614-23-6 1,2,2,3,3,6,6-heptamethyl-4-piperidol 
• 134614-28-1 1,2,2,3,3,4,6,6-octamethyl-4-piperidol 
• 1356450-65-1 C₃₅H₅₈N₂O₄ 

Relevant articles and documents

Green synthesis method of 1,2,2,6,6-pentamethyl-4-piperidone

The invention discloses a green synthesis method of 1,2,2,6,6-pentamethyl-4-piperidone. 2,2,6,6-tetramethylpiperidone and DMC which serve as raw materials are stirred and reacted at a certain temperature for a certain time under the actions of a solvent and a catalyst, cooling, filtering, concentrating and negative pressure rectification are carried out after the reaction is finished in order to obtain the final product 1,2,2,6,6-pentamethyl-4-piperidone, and yield can reach 90%. Toxic and harmful dimethyl sulfate, chloroform, methyl iodide, formaldehyde, formic acid and the like are not usedin the whole synthesis process, no wastewater is discharged in the production process, and the method is a green synthesis mode of 1,2,2,6,6-pentamethyl-4-piperidone.

Platinum-(phosphinito-phosphinous acid) complexes as bi-talented catalysts for oxidative fragmentation of piperidinols: An entry to primary amines

Platinum-(phosphinito-phosphinous acid) complex catalyzes the oxidative fragmentation of hindered piperidinols according to a hydrogen transfer induced methodology. This catalyst acts successively as both a hydrogen carrier and soft Lewis acid in a one pot-two steps process. This method can be applied to the synthesis of a wide variety of primary amines in a pure form by a simple acid-base extraction without further purification.

Synthesis method of 1,2,2,6,6-pentamethyl-4-piperidone

The invention provides a synthesis method of 1,2,2,6,6-pentamethyl-4-piperidone. The synthesis method comprises the following steps: adding acetone and methylamine into a reaction kettle according toa proportion; then adding a catalyst, and stirring for carrying out reaction, wherein the catalyst is prepared from sulfonic acid functionalized SBA-15; after the reaction is finished, adding an alkali quenching catalyst, and then filtering out the catalyst to obtain a crude product of the 1,2,2,6,6-pentamethyl-4-piperidone; purifying the obtained crude product to obtain the pure 1,2,2,6,6-pentamethyl-4-piperidone product. The synthesis method, provided by the invention, of the1,2,2,6,6-pentamethyl-4-piperidone is high in product yield, economical, efficient and environmentally friendly, thusbeing very suitable for industrial production.