55560-96-8 Usage
Description
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate), also known as Tixocortol 21-Pivalate, is a chemical compound derived from the steroid class. It is characterized by its pale yellow solid appearance and is a pivalate thioester of tixocortol. S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) possesses unique chemical properties that make it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) is used as an anti-inflammatory agent for its potent anti-inflammatory properties. It is particularly effective in managing inflammation and related conditions.
Used in Research and Development:
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) is used as a free thiol in chemoaffinity labeling. This application is crucial in the field of research and development, as it aids in the identification and characterization of various biomolecules.
Used in Biotechnology Industry:
In the biotechnology industry, S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) is used for fluorescent chemoaffinity labeling. This technique is essential for studying protein-protein interactions, enzymesubstrate interactions, and other biological processes at the molecular level.
Used in Diagnostics:
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) is also utilized in the development of diagnostic tools and assays, particularly in the detection and analysis of various biomarkers and molecular targets.
Originator
Pivalone,Jouveinal,France,1978
Manufacturing Process
In a reactor of 50 liters, sodium S-thiopivalate is prepared from 100 g of S_x0002_thiopivalic acid (0.844 mol), 214 cc of solution of sodium methylate, 3.95 M
(0.844 mol) in 25 liters of anhydrous acetone.
There are then added 285 g (0.603 mol) of dihydroxy-11β,17α-iodo-21-dioxo-
3,20-pregnene-4 and the mixture is brought up to the acetone reflux for two
hours. The solvent is eliminated by distillation under vacuum until there is
obtained a syrupy residue which is poured into 10 liters of iced water. The
insoluble part is filtered and dried under vacuum.
The crude product is purified by recrystallization from ethanol; weight: 250 g;
yield: 89.5%.
Therapeutic Function
Antiinflammatory
Contact allergens
Tixocortol 21-pivalate is a 21-ester of tixocortol, widely
used in topical treatments. It can induce severe allergic
contact dermatitis. This corticosteroid is a marker of the
allergenic A group that includes molecules without
major substitution on the D cycle (no C 16 methylation,
no C 17 side chain). A short-chain C 21 ester is possible.
Molecules are cloprednol, cortisone, fludrocortisone,
fluorometholone, hydrocortisone, methylprednisolone,
methylprednisone, prednisolone, prednisone, tixocor-
tol, and their C 21 esters (acetate, caproate or hexanoate,
phosphate, pivalate or trimethylacetate, succinate or
hemisuccinate, m-sulfobenzoate).
Check Digit Verification of cas no
The CAS Registry Mumber 55560-96-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,5,6 and 0 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 55560-96:
(7*5)+(6*5)+(5*5)+(4*6)+(3*0)+(2*9)+(1*6)=138
138 % 10 = 8
So 55560-96-8 is a valid CAS Registry Number.
InChI:InChI=1/C26H38O5S/c1-23(2,3)22(30)32-14-20(29)26(31)11-9-18-17-7-6-15-12-16(27)8-10-24(15,4)21(17)19(28)13-25(18,26)5/h12,17-19,21,28,31H,6-11,13-14H2,1-5H3/t17-,18-,19-,21+,24-,25-,26-/m0/s1
