55579-46-9

Basic information

• Product Name: 1,9(2H,10H)-Acridinedione, 7-chloro-3-(4-chlorophenyl)-3,4-dihydro-10-hydroxy-
• CAS NO: 55579-46-9
• Molecular Formula: C19H13Cl2NO3
• Molecular Weight: 374.223
• Mol File: 55579-46-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,9(2H,10H)-Acridinedione, 7-chloro-3-(4-chlorophenyl)-3,4-dihydro-10-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,9(2H,10H)-Acridinedione, 7-chloro-3-(4-chlorophenyl)-3,4-dihydro-10-hydroxy-(55579-46-9)
• EPA Substance Registry System: 1,9(2H,10H)-Acridinedione, 7-chloro-3-(4-chlorophenyl)-3,4-dihydro-10-hydroxy-(55579-46-9)

Safety Data

• Hazardous Substances Data: 55579-46-9(Hazardous Substances Data)

Upstream product

• 27463-38-3 5-(4-chlorophenyl)cyclohexane-1,3-dione 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 133929-38-1 9-Chloro-4-(4-chloro-phenyl)-4,5-dihydro-3H-1-oxa-2,6-diaza-aceanthrylene 6-oxide 
• 75638-12-9 7-chloro-3-(4-chlorophenyl)-1,10-dihydroxy-9(10H)-acridone 
• 133929-31-4 7-Chloro-3-(4-chloro-phenyl)-10-hydroxy-3,4-dihydro-2H,10H-acridine-1,9-dione 1-oxime 

Relevant articles and documents

Antimalarial compositions

Antimalarial compositions are disclosed containing as the active ingredient a mixture of a tetrahydroacridone of the general formula I STR1 in which R1 represents methyl, phenyl, p-chlorophenyl, m-chlorophenyl, p-fluorophenyl, p-trifluoromethylphenyl, o-trifluoromethylphenyl or o-chloro-p-trifluoromethylphenyl, R2 represents hydrogen or methyl, and R3 represents fluorine or chlorine, or a salt of such a compound with a physiologically compatible acid or base, with (a) 6-methoxy-α-(5-vinyl-2-quinuclidinyl)-4-quinoline-methanol (Quinine), (b) 7-chloro-4-(diethylamino-1-methyl-butylamino)-quinoline (Chloroquine), (c) α-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (Mefloquine), (d) 8-(4-amino-1-methylbutylamino)-6-methoxy-quinoline (Primaquine), (e) 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine (Pyrimethamine), (f) 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine (Cycloguanil), (g) 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine (Trimethoprim), (h) N'-(5,6-dimethoxy-4-pyrimidyl)-sulfanilamide (Sulfadoxine), or (i) 4,4'-diaminodiphenylsulfone (Dapsone), or with a salt of a compound sub (a) to (i), with a physiologically compatible acid or base, the mixtures being in a proportion by weight of between 25:1 and 1:300 (tetrahydroacridone to compound sub (a) to (i)) in admixture with a pharmaceutically acceptable carrier and/or adjuvant.

Tetrahydroacridones having chemotherapeutic action and process for preparing them

Tetrahydroacridones and their salts with physiologically tolerated acids and bases and process for preparing them. The compounds have a valuable chemotherapeutic action and may be used as drugs against protozoan diseases.