55582-10-0Relevant articles and documents
Synthesis of (+)-Lentiginosine and Its Pyrrolizidine Analogue Based on Intramolecular Cyclization of α-Sulfinyl Carbanions
Du-A-Man, Sakkarin,Soorukram, Darunee,Kuhakarn, Chutima,Tuchinda, Patoomratana,Reutrakul, Vichai,Pohmakotr, Manat
, p. 1708 - 1715 (2014)
A synthesis of (+)-lentiginosine and its pyrrolizidine analogue was accomplished in six steps, starting from L-(+)-tartaric acid. The key step of these syntheses involves the intramolecular cyclization of α-sulfinyl carbanions for the construction of the indolizidine or pyrrolizidine ring.
Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents
Hu, Kun,Qi, Yan-Jie,Zhao, Juan,Jiang, He-Fei,Chen, Xin,Ren, Jie
, p. 529 - 539 (2013/07/11)
A series of sulforaphane derivatives were synthesized and evaluated in vitro for their cytotoxicity against five cancer cell lines (HepG2, A549, MCF-7, HCT-116 and SH-SY5Y). The pharmacological results showed that many of the derivatives displayed more potent cytotoxicity than sulforaphane (SFN). Furthermore, SFN and derivative 85 could induce cell cycle arrest at S or G2/M phase and cell apoptosis. SFN and 85 exhibited time- and dose-dependent activation on Nrf2 transcription factor, and 85 acted as a more potent Nrf2 inducer than SFN.
Photochemistry of the Phthalimide System, 37. - Thiazacycloalkanols by Photocyclization of S-Substituted N-(Thioalkyl)phthalimides
Sato, Yasuhiko,Nakai, Hideo,Wada, Masao,Mizoguchi, Tomishige,Hatanaka, Yasumaru,et al.
, p. 1099 - 1118 (2007/10/02)
N-Substituted phthalimides (1,2) possessing a terminal thioether function in their side chain were irradiated with a high-pressure mercury lamp to give a variety of thiazacycloalkanol derivatives (3,7,9-13,16,17) with favored γ-, δ-, ε-, and ζ-hydrogen abstractions (Table 1), in moderate to fairly good yields.
