55614-10-3 Usage
Description
ARG-PRO-LYS-PRO-GLN-GLN-PHE-TYR-GLY-LEU-MET-NH2, also known as [Tyr8] Substance P, is a neurotransmitter peptide that plays a crucial role in the regulation of various physiological processes, including pain, depression, and neurodegenerative diseases. It is composed of a sequence of eleven amino acids, with the tyrosine at the eighth position being particularly significant for its biological activities.
Uses
Used in Pharmaceutical Industry:
[Tyr8] Substance P is used as a therapeutic agent for the treatment of pain, depression, and neurodegenerative diseases. Its ability to modulate the nervous system and interact with specific receptors makes it a promising candidate for the development of new drugs targeting these conditions.
Used in Research and Development:
[Tyr8] Substance P is used as a research tool in the field of neuroscience to study the underlying mechanisms of pain perception, mood regulation, and neurodegenerative processes. It helps researchers understand the complex interactions between neurotransmitters and their receptors, which can lead to the discovery of novel therapeutic strategies.
Used in Drug Delivery Systems:
Similar to gallotannin, [Tyr8] Substance P can also be incorporated into drug delivery systems to enhance its bioavailability, targeting, and therapeutic efficacy. These systems can be designed to specifically deliver the peptide to the desired site of action, reducing potential side effects and improving treatment outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 55614-10-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,6,1 and 4 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 55614-10:
(7*5)+(6*5)+(5*6)+(4*1)+(3*4)+(2*1)+(1*0)=113
113 % 10 = 3
So 55614-10-3 is a valid CAS Registry Number.
55614-10-3Relevant articles and documents
Synthesis and Radioiodination of Analogues of Substance P for the Building up of a Radioimmunoassay
Bienert, M.,Schmidt, H. E.,Ehrlich, A.,Forner, K.,Klauschenz, E.,et al.
, p. 97 - 100 (2007/10/02)
The substance P (SP) analogs 3>-SP, 8>-SP, 8, Nle11>-SP and 1>-SP have been synthesized by classical methods of peptide synthesis as well as by the liquid phase peptide synthesis (LPPS) to allow conjugation with protein in the Nα-position and radioiodination. 8>-SP and 1>-SP have been radioiodinated by the chloramine T- and the lactoperoxidase method.A complete S-oxidation of SP was observed, when the chloramine T procedure was used, but this modification does not disturbe the assay.The introduction of the 1>-SP-tracer led to considerable improvements of our SP-radioimmunoassay.