55653-03-7

Basic information

• Product Name: [2-(2-chlorophenyl)hydrazinylidene]propanedinitrile
• Synonyms: [(2-Chlorophenyl)hydrazono]malononitrile; propanedinitrile, 2-[2-(2-chlorophenyl)hydrazinylidene]-
• CAS NO: 55653-03-7
• Molecular Formula: C₉H₅ClN₄
• Molecular Weight: 204.6158
• Mol File: 55653-03-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 315°C at 760 mmHg
• Flash Point: 144.3°C
• Density: 1.26g/cm³
• Vapor Pressure: 0.00045mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: [2-(2-chlorophenyl)hydrazinylidene]propanedinitrile(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(2-chlorophenyl)hydrazinylidene]propanedinitrile(55653-03-7)
• EPA Substance Registry System: [2-(2-chlorophenyl)hydrazinylidene]propanedinitrile(55653-03-7)

Safety Data

• Hazardous Substances Data: 55653-03-7(Hazardous Substances Data)

Usage

Description

[2-(2-chlorophenyl)hydrazinylidene]propanedinitrile is a chemical compound characterized by its molecular formula C9H6ClN3. It features a hydrazine functional group connected to a 2-chlorophenyl group, with a propanedinitrile chain. [2-(2-chlorophenyl)hydrazinylidene]propanedinitrile is a yellow to brown solid at room temperature and is known for its unique structure and reactivity, which makes it valuable in chemical research and synthesis.

Uses

Used in Chemical Research and Synthesis:
[2-(2-chlorophenyl)hydrazinylidene]propanedinitrile is used as a reagent in chemical research and synthesis for its distinctive structure and reactivity. It can be employed to create a variety of compounds with different applications across various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, [2-(2-chlorophenyl)hydrazinylidene]propanedinitrile is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique properties allow for the development of new drugs with potential therapeutic benefits.
Used in Material Science:
[2-(2-chlorophenyl)hydrazinylidene]propanedinitrile is also used in material science as a component in the development of novel materials with specific properties. Its incorporation into these materials can lead to enhanced performance characteristics.
It is crucial to handle and use [2-(2-chlorophenyl)hydrazinylidene]propanedinitrile with care, adhering to proper safety precautions and guidelines to minimize any potential risks associated with its use.

Upstream product

• 95-51-2 o-chloroaniline 
• 109-77-3 malononitrile 
• 922-64-5 1,1-dicyanoethylene 

Downstream Products

• 1149376-69-1 2-chlorophenylhydrazono-1H-tetrazol-5-yl-acetonitrile 

Relevant articles and documents

COMPOUNDS HAVING PSEUDOMONAS ANTI-BIOFILM PROPERTIES

The present invention relates to c-di-GMP lowering chemical compounds having anti- biofilm properties. In particular, the present invention relates to anti-biofilm compounds or salts or tautomers thereof for use in treatment and/or prevention of bacterial biofilm infection in human subjects caused by biofilm-forming bacteria of the genus Pseudomonas, in particular Pseudomonas spp. including P. aeruginosa. Methods of treating such infections in human subjects are contemplated as well. The present inventions further relates to the use of an anti-biofilm compound or a salt or tautomer thereof for dispersing biofilms in industrial water systems.

Novel heterocyclic disazo dyes containing pyrazole and phenylpyrazole. part 1: Synthesis, characterization, solvent polarity and acid-base sensitive characteristics

A series of diazotised aniline and aniline derivative compounds were reacted with solution of malononitrile in pyridine at 0–5 °C were obtained 1a-1m compounds. Then 4-arylazo-3,5-diamino-1H-pyrazole (2a-2m) derivatives were synthesized by coupling arylazo malononitrile compounds with hydrazine. Finally, the synthesized pyrazole derivative 2a-2m compounds were again diazotised. By reacting these diazotised compounds with 3-amino-5?hydroxy-1-phenylpyrazole, the new thirteen heterocyclic disazo dyes (3a-3m) were joined the dye literature and the dye industry. The structures of these newly synthesized compounds were characterized using elemental analysis and spectroscopic methods such as Fourier transform infrared spectroscopy-Attenuated total reflectance (FT-IR-ATR), 1H-Nuclear magnetic resonance (1H NMR) spectroscopy and mass spectroscopy. Then solvatochromic properties and solvent effect in dimethyl sulfoxide, dimethyl formamide, acetonitrile, acetic acid, methanol and chloroform were investigated. In addition, the effects of organic and inorganic acids and bases on the absorption spectra of the compounds and the substituent effect of the phenyl ring-bound groups were investigated.

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate as an HIV-1 replication inhibitor

Inspired by the antiviral activity of known pyrazole-based HIV inhibitors, we screened our in-house library of pyrazole-based compounds to evaluate theirin celluloactivity against HIV-1 replication. Two hits with very similar structures appeared from single and multiple-round infection assays to be non-toxic and active in a dose-dependent manner. Chemical expansion of their series allowed an in-depth and consistent structure-activity-relationship study (SAR) to be built. Further ADME evaluation led to the selection of 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate with an advantageous pharmacokinetic profile. Finally, examination of its mode of action revealed that this compound does not belong to the three main classes of anti-HIV drugs, a feature of prime interest in the context of viral resistance.