55694-81-0

Basic information

• Product Name: 1-Methyl-1H-iMidazole-2-sulfonyl chloride
• Synonyms: 1-Methyl-1H-iMidazole-2-sulfonyl chloride;1-Methylimidazole-2-sulfonyl chloride;2-Chlorosulfonyl-1-methylimidazole;1-MethyliMidazole-2-sulfonyl chloride 95%
• CAS NO: 55694-81-0
• Molecular Formula: C₄H₅ClN₂O₂S
• Molecular Weight: 180.6127
• Product Categories: Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Imidazoles
• Mol File: 55694-81-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 66-71℃
• Boiling Point: 355.842 °C at 760 mmHg
• Flash Point: 169.007 °C
• Appearance: /
• Density: 1.605 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-1H-iMidazole-2-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-iMidazole-2-sulfonyl chloride(55694-81-0)
• EPA Substance Registry System: 1-Methyl-1H-iMidazole-2-sulfonyl chloride(55694-81-0)

Safety Data

• Hazard Codes: C
• Statements: 34-43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 55694-81-0(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-imidazole-2-sulfonyl chloride is a chemical compound with the molecular formula C6H7ClN2O2S. It is a sulfonyl chloride derivative of 1-methyl-1H-imidazole, and it is commonly used in organic synthesis as a reagent for the preparation of various pharmaceutical compounds. 1-Methyl-1H-iMidazole-2-sulfonyl chloride is a white to off-white solid that is highly reactive and can react violently with water, so it must be handled with care. Its main applications include the synthesis of sulfonylurea herbicides and the preparation of pharmaceutical intermediates. Additionally, it is used as a building block in the synthesis of various heterocyclic compounds.

Upstream product

• 60-56-0 2-Mercapto-1-methylimidazole 

Downstream Products

• 1621914-65-5 1-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-(1-methylimidazol-2-ylsulfonyl)piperazine 
• 1359937-95-3 ethyl 1-benzyl-6-(2-(1-methyl-1H-imidazole-2-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-ylcarbamate 

Relevant articles and documents

NaClO2-mediated preparation of pyridine-2-sulfonyl chlorides and synthesis of chiral sulfonamides

A simple method to prepare azaarenesulfonyl chlorides by NaClO2-mediated oxidative chlorination of azaarenethiols have been developed, with water as the solvent. Easy purification by simple extraction and concentration gives the products in good yields. The azaarenesulfonyl chlorides readily undergo condensation with chiral amines to afford chiral sulfonamides.

Sulphonamido-Substituted Cyclohexyl Sulphones for Treatment of Cancer

Compounds of formula (I) are disclosed for treatment of cancer.

Synthesis of chiral heteroaromatic tetradentate sulfonamide based ligands

We report a facile two step synthesis of chiral tetradentate ligands for late metal complexes. The ligands are easily prepared from trans-1,2- diaminocyclohexane or chiral 1,2-diphenylethylenediamine and a heteroaromatic sulfonyl chloride in the presence of base (K2CO3 or Et3N). These compounds represent a new class of chiral tetradentate N2S2 and N4 based ligands.