5577-20-8

Basic information

• Product Name: Benzenamine, 4-(1,3,2-dithiarsolan-2-yl)-
• Synonyms: 2-p-Aminophenyl-1.3.2-dithiarsenolane;2-aminophenyl-1,3,2-dithiaarsolane;2-p-aminophenyl-1,3,2-dithiarsenolane;4-[1,3,2]dithiarsolan-2-yl-aniline
• CAS NO: 5577-20-8
• Molecular Formula: C8H10AsNS2
• Molecular Weight: 259.228
• Mol File: 5577-20-8.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-(1,3,2-dithiarsolan-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-(1,3,2-dithiarsolan-2-yl)-(5577-20-8)
• EPA Substance Registry System: Benzenamine, 4-(1,3,2-dithiarsolan-2-yl)-(5577-20-8)

Safety Data

• Hazardous Substances Data: 5577-20-8(Hazardous Substances Data)

Usage

General Description

Benzenamine, 4-(1,3,2-dithiarsolan-2-yl)- is a chemical compound that contains a benzene ring and a 1,3,2-dithiarsolan-2-yl group. Benzenamine, 4-(1,3,2-dithiarsolan-2-yl)- is also known as phenyl-1,3,2-dithiarsolane. It is a synthetic organoarsenic compound and is not naturally occurring. It is commonly used in the laboratory for research purposes and in the production of other organic compounds. Its specific properties and applications may vary depending on the specific chemical reactions and processes in which it is involved.

Upstream product

• 79368-82-4 p-aminophenyldichloroarsine 
• 540-63-6 ethane-1,2-dithiol 
• 5410-78-6 p-aminophenyldichloroarsine. hydrochloride 
• 98-50-0 p-aminophenylarsonic acid 
• 1122-90-3 4-aminophenylarsenoxide 

Downstream Products

• 4723-99-3 1,2-bis-dithiarsolan-2-ylmercapto-ethane 
• 1334715-61-5 tert-butyl 6-(4-(1,3,2-dithiarsolan-2-yl)phenylamino)-6-oxohexylcarbamate 
• 1334715-64-8 N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-aminohexanamide 
• 1334715-70-6 NPE 
• 1334715-67-1 N-(4-(1,3,2-dithiarsolan-2-yl)phenyl)-6-(6-bromo-7-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanamide 

Relevant articles and documents

A Fluorescent Probe for Stimulated Emission Depletion Super-Resolution Imaging of Vicinal-Dithiol-Proteins on Mitochondrial Membrane

Realizing the significant roles of vicinal-dithiol proteins (VDPs) in maintaining the cellular redox homeostasis and their implication in many diseases, we synthesized a smart arsenate based fluorescent probe 1 which can preferentially target the mitochon

Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin

The mechanisms of action of arsenic trioxide (ATO), a clinically used drug for the treatment of acute promyelocytic leukemia (APL), have been actively studied mainly through characterization of individual putative protein targets. There appear to be no studies at a system level. Herein, we integrate metalloproteomics through a newly developed organoarsenic probe, As-AC (C20H17AsN4O3S2) with quantitative proteomics, allowing 37 arsenic binding and 250 arsenic regulated proteins to be identified in NB4, a human APL cell line. Bioinformatics analysis reveals that ATO disrupts multiple physiological processes, in particular, chaperone-related protein folding and cellular response to stress. Furthermore, we discover heat shock protein 60 (Hsp60) as a vital target of ATO. Through biophysical and cell-based assays, we demonstrate that ATO binds to Hsp60, leading to abolishment of Hsp60 refolding capability. Significantly, the binding of ATO to Hsp60 disrupts the formation of Hsp60-p53 and Hsp60-survivin complexes, resulting in degradation of p53 and survivin. This study provides significant insights into the mechanism of action of ATO at a systemic perspective, and serves as guidance for the rational design of metal-based anticancer drugs. This journal is

Fluorescent probe compound for detecting Vicinal dithiol protein in live cells and a Vicinal dithiol protein detection fluorescence sensor comprising the same

The present invention relates to a fluorescent probe compound for detecting a non-cyhalodithiol protein represented by chemical formula 1, and a fluorescent sensor for detecting a non-optic dithiol protein comprising the same. Chemical Formula 1. . (by machine translation)