55774-34-0

Basic information

• Product Name: 5-(ETHYLAMINO)-1,3,4-THIADIAZOLE-2-THIOL
• Synonyms: 1,3,4-Thiadiazole-2-thiol,5-ethylamino- (6CI);2-Ethylamino-5-mercapto-1,3,4-thiadiazole;5-(Ethylamino)-1,3,4-thiadiazole-2(3H)-thione;5-(Ethylamino)-1,3,4-thiadiazole-2-thiol;5-Ethylamino-3H-[1,3,4]thiadiazole-2-thione
• CAS NO: 55774-34-0
• Molecular Formula: C₄H₇N₃S₂
• Molecular Weight: 161.25
• Mol File: 55774-34-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 224.9 °C at 760 mmHg
• Flash Point: 89.8 °C
• Appearance: /
• Density: 1.54 g/cm³
• Vapor Pressure: 0.0887mmHg at 25°C
• Refractive Index: 1.748
• CAS DataBase Reference: 5-(ETHYLAMINO)-1,3,4-THIADIAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(ETHYLAMINO)-1,3,4-THIADIAZOLE-2-THIOL(55774-34-0)
• EPA Substance Registry System: 5-(ETHYLAMINO)-1,3,4-THIADIAZOLE-2-THIOL(55774-34-0)

Safety Data

• Hazardous Substances Data: 55774-34-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H7N3S2/c1-2-5-3-6-7-4(8)9-3/h2H2,1H3,(H,5,6)(H,7,8)

Upstream product

• 75-15-0 carbon disulfide 
• 13431-34-0 N-ethylthiosemicarbazide 

Downstream Products

• 79010-45-0 ethyl-(benzylmercapto-[1,3,4]thiadiazol-2-yl)-amine 

Relevant articles and documents

CERTAIN NEW 4-(2-((5-(SUBSTITUTEDAMINO)-1,3,4-THIADIAZOLE-2-YL)THIO)ACETYL)BENZENESULPHONEAMIDE DERIVATIVES AND A METHOD FOR THE SYNTHESIS OF SAID DERIVATIVES

The invention relates to a certain new 4-(2-((5-(substitutedamino)-1,3,4-thiadiazole-2-yl)thio)acetyl)benzenesulphonamide derivatives for use in pharmaceutics, chemical and pharmaceutical industry, and to a method for the synthesis of said derivatives.

Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents

Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. The structures of the obtained compounds were elucidated using 1H-NMR, 13C-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.

Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

A series of thiadiazole derivatives has been designed as potential allosteric, substrate competitive inhibitors of the protein kinase JNK. We report on the synthesis, characterization and evaluation of a series of compounds that resulted in the identifica