55779-18-5 Usage
Description
Arprinocide, also known by the brand name Arpocox (Merck), is a pale yellow solid with significant applications in the field of veterinary medicine. It is a potent coccidiostat, which means it is used to prevent and treat coccidiosis, a disease caused by the protozoan parasite Eimeria in poultry.
Uses
Used in Veterinary Medicine:
Arprinocide is used as a coccidiostat for the prevention and treatment of coccidiosis in poultry. It is effective against various species of Eimeria, which are responsible for causing this disease. By controlling the growth and proliferation of these parasites, Arprinocide helps maintain the health and productivity of the birds.
Originator
Arprinocid,NANJING PHARMA
Manufacturing Process
To a solution of potassium t-butoxide in absolute ethanol slowly adding dry
adenine. This mixture was stirred for about 2 h, and then 2-chloro-6-
fluorobenzyl chloride was added over a period of about 4 h. The resulting
mixture was heated to reflux with stirring and allowed to react for about 42 h,
after which it was cooled to about 10°C. The crude product thus formed was
isolated by filtration and then washed with ice cold ethanol and ice cold water
to yield a 6-amino-9-(2-chloro-6-fluorobenzyl)purine.
Synthesis Reference(s)
The Journal of Organic Chemistry, 43, p. 960, 1978 DOI: 10.1021/jo00399a034
Check Digit Verification of cas no
The CAS Registry Mumber 55779-18-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,7,7 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 55779-18:
(7*5)+(6*5)+(5*7)+(4*7)+(3*9)+(2*1)+(1*8)=165
165 % 10 = 5
So 55779-18-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H9ClFN5/c13-8-2-1-3-9(14)7(8)4-19-6-18-10-11(15)16-5-17-12(10)19/h1-3,5-6H,4H2,(H2,15,16,17)
55779-18-5Relevant articles and documents
Specific Dealkylation of 3-Benzyladenines in the Presence of 9-Benzyladenines
Weinstock, Leonard M.,Tull, Roger J.,Douglas, Alan W.,Shinkai, Ichiro
, p. 5419 - 5421 (1980)
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Process for formulating a synthetic drug for use in animal feed, and resulting formulation
-
, (2008/06/13)
A method of formulating a synthetic drug for use in animal feed, for the purpose of reducing carry-over of the synthetic drug to subsequent lots of animal feed in the feed mill.
Phase-Transfer Catalysis in the N-Benzylation of Adenine
Shinkai, I.,Zwan, M. C. Vander,Hartner, F. W.,Reamer, R. A.,Tull, R. J.,Weinstock, L. M.
, p. 197 - 198 (2007/10/02)
A convenient phase-transfer catalysis in the N-benzylation of adenine is described.The benzylation of adenine with benzyl halides in a two-phase system containing phase-transfer catalyst gave 9-benzylated adenines as a major product accompanied with 3-benzylated adenines.