55796-74-2Relevant articles and documents
Transition-Metal-Free Synthesis of Unsymmetrical Disulfides via Three-Component Reaction of Thiosulfonates, Thiourea and Alkyl halides
Wang, Dungai,He, Quan,Shi, Keqiang,Xiong, Mingteng,Zhou, Yifeng,Pan, Yuanjiang
, p. 2767 - 2772 (2021/04/19)
A transition-metal-free approach to synthesize unsymmetrical disulfides is reported that relies on a K2CO3-promoted one-pot reaction of thiosulfonates, thiourea and alkyl halides under mild conditions. The protocol tolerates a wide range of substrates, leading to various types of unsymmetrical disulfides in moderate to excellent yields. More importantly, the late-stage modification of natural products and drug molecules was also achieved. (Figure presented.).
2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS
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Page/Page column 31; 32, (2013/03/26)
The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type
A versatile thiouronium-based solid-phase synthesis of 1,3,5-triazines
Kong, Kah Hoe,Tan, Chong Kiat,Lin, Xijie,Lam, Yulin
experimental part, p. 1476 - 1486 (2012/03/26)
A thiouronium-based solidphase synthesis of a 1,3,5-triazine scaffold has been developed. The key feature of the synthesis is the use of a readily accessible solid-supported thiouronium salt as a primary precursor for the stepwise assembly of the 1,3,5-tri-azine substrate. The sulfur linker employed in the synthesis is stable under both acidic and basic conditions and is versatile enough to provide access to monocyclic, bicyclic, and spirocyclic compounds with the 1,3,5-triazine scaffold. By using this synthetic strategy, a representative set of 79 compounds containing the 1,3,5-triazine scaffold were prepared.
