55844-94-5

Basic information

• Product Name: MERRIFIELD RESIN
• Synonyms: STRATOSPHERES(TM) PL-CMS RESIN;PL-CMS MP-RESIN;PL-CMS RESIN;POLY(STYRENE-CO-CHLOROMETHYLSTYRENE);POLY(STYRENE-CO-VINYLBENZYL CHLORIDE-CO-DIVINYLBENZENE);POLYSTYRENE CROSSLINKED WITH DIVINYLBENZENE, CHLOROMETHYLATED;ULTRASUBSTITUTED MERRIFIELD RESIN;4-CHLOROMETHYL RESIN
• CAS NO: 55844-94-5
• Molecular Weight: 602.70038
• EINECS: -0
• Product Categories: Combinatorial Chemistry;Resins;Synthetic Organic Chemistry
• Mol File: 55844-94-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 536.1°C at 760 mmHg
• Flash Point: 250.2°C
• Appearance: /porous
• Vapor Pressure: 5.01E-11mmHg at 25°C
• Refractive Index: 1.4385
• Storage Temp.: 2-8°C
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: MERRIFIELD RESIN(CAS DataBase Reference)
• NIST Chemistry Reference: MERRIFIELD RESIN(55844-94-5)
• EPA Substance Registry System: MERRIFIELD RESIN(55844-94-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25-22
• WGK Germany: 3
• Hazardous Substances Data: 55844-94-5(Hazardous Substances Data)

Usage

Description

MERRIFIELD RESIN, also known as Merrifield's Insoluble Peptide Resin Support, is a copolymer of chloromethyl polystyrene and styrene monomers. It is a white polymer bead that serves as an insoluble support for the synthesis of peptide acids using the Boc strategy. The Merrifield Resin is synthesized by copolymerizing chloromethyl polystyrene and styrene monomers, avoiding the use of carcinogenic chloromethyl methyl ether. This resin is a crucial component in the Merrifield Synthesis method, which is a widely used technique for the solid-phase synthesis of polypeptide chains.

Uses

Used in Pharmaceutical Industry:
MERRIFIELD RESIN is used as a solid-phase support for the synthesis of peptide acids using the Boc strategy. This application is essential in the development of various pharmaceutical compounds, including drugs and therapeutic agents.
Used in Merrifield Synthesis:
MERRIFIELD RESIN is used as an insoluble support in the Merrifield Synthesis of polypeptide chains, facilitated by DCC (dicyclohexylcarbodiimide). This method allows for the stepwise addition of amino acids to form the desired polypeptide sequence, making it a valuable tool in peptide synthesis.
Used in Research and Development:
MERRIFIELD RESIN is used as a research tool for the development of new peptide-based compounds and the study of peptide synthesis methods. It is also used in the synthesis of different Boc protected amino acids, which are available from stock for further research and development purposes.
Chemical Properties:
MERRIFIELD RESIN is a white polymer bead with unique chemical properties that make it suitable for use in peptide synthesis. It provides an insoluble support for the Boc strategy, allowing for the efficient and controlled synthesis of peptide acids.

InChI:InChI=1/C10H10.C9H9Cl.C8H8/c1-3-9-5-7-10(4-2)8-6-9;1-2-8-3-5-9(7-10)6-4-8;1-2-8-6-4-3-5-7-8/h3-8H,1-2H2;2-6H,1,7H2;2-7H,1H2