55860-23-6 Usage
Description
3-CHLORO-N-(2-METHOXYPHENYL)PROPANAMIDE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its amide functional group and a chloro substituent, which contribute to its reactivity and potential applications in the chemical and pharmaceutical industries.
Uses
Used in Pharmaceutical Synthesis:
3-CHLORO-N-(2-METHOXYPHENYL)PROPANAMIDE is used as an intermediate in the synthesis of 8-Hydroxy-3,4-dihydro-2(1H)-quinolinone (H941405), which is involved in the studies of salvianolic acid B metabolites. This application highlights its importance in the development of novel therapeutic agents and the understanding of their metabolic pathways.
Used in the Synthesis of Aripiprazole Impurity 5:
In the pharmaceutical industry, 3-CHLORO-N-(2-METHOXYPHENYL)PROPANAMIDE is also utilized in the synthesis of Aripiprazole Impurity 5. Aripiprazole is an atypical antipsychotic drug used to treat various psychiatric disorders, such as schizophrenia and bipolar disorder. The synthesis of its impurities, including Impurity 5, is essential for quality control and safety assessments of the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 55860-23-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,8,6 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55860-23:
(7*5)+(6*5)+(5*8)+(4*6)+(3*0)+(2*2)+(1*3)=136
136 % 10 = 6
So 55860-23-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H12ClNO2/c1-14-9-5-3-2-4-8(9)12-10(13)6-7-11/h2-5H,6-7H2,1H3,(H,12,13)
55860-23-6Relevant articles and documents
Synthesis of novel 3,4-dihydroquinolin-2(1H)-one guanidines as potential antihypertensive agents
Pai,Samel
experimental part, p. 1655 - 1660 (2012/01/06)
Hydroxy-3,4-dihydroquinolin-2(1H)-ones (4a-c) were synthesized by intramolecular Friedel Craft alkylation of N-(methoxyphenyl)-3- chloropropionamides (3a-c), obtained by acylation of anisidine with chloropropionyl chloride. The hydroxy-3,4-dihydro quinolin-2(1H)- ones (4a-c) were treated with various dibromo alkanes under phase transfer catalyst conditions at room temperature to give bromoalkyloxy- 3,4-dihydroquinolin-2(1H)- ones (5a-l) which on further reaction with guanidine hydrochloride in dimethyl formamide afforded N-{4- [(2-oxo-1,2,3,4-tetrahydroquinolin-5-yl)oxy]alkyl} guanidines (6a-l). These compounds were synthesized as potential antihypertensive agents.
Synthesis and anticonvulsant activity of some ω-(1H-1-imidazolyl)-N- phenylalkanoic acid amide derivatives
Aktuerk, Zeynep,Kilic, Fatma,Erol, Kevser,Pabuccuoglu, Varol
, p. 201 - 206 (2007/10/03)
In this study, 15 ω-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their antic
