55865-51-5 Usage
Description
(2-Amino-3-thienyl)(4-chlorophenyl)methanone is a chemical compound with the molecular formula C11H8ClNOS. It is a ketone derivative featuring a thienyl ring and a chlorophenyl group attached to the methanone functional group. (2-AMINO-3-THIENYL)(4-CHLOROPHENYL)METHANONE is recognized for its potential as a building block in the synthesis of various biologically active compounds, making it a versatile precursor in pharmaceutical and chemical research.
Uses
Used in Pharmaceutical Industry:
(2-Amino-3-thienyl)(4-chlorophenyl)methanone is used as a key intermediate in the development of drugs for treating a range of diseases, including cancer, inflammation, and neurological disorders. Its unique structure allows for the creation of novel compounds with potential therapeutic value, contributing to advancements in medicinal chemistry.
Used in Chemical Research:
In the realm of chemical research, (2-Amino-3-thienyl)(4-chlorophenyl)methanone serves as a valuable building block for the synthesis of new chemical entities. Its structural properties enable the exploration of diverse applications, from enhancing existing compounds to creating entirely new ones with a broad spectrum of uses.
Used as a Reagent in Organic Synthesis:
(2-Amino-3-thienyl)(4-chlorophenyl)methanone is also utilized as a reagent in organic synthesis, where it aids in the creation of chemical entities with distinct properties. Its role in this process is crucial for expanding the scope of chemical compounds available for various applications, further highlighting its importance in the field of chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 55865-51-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,8,6 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 55865-51:
(7*5)+(6*5)+(5*8)+(4*6)+(3*5)+(2*5)+(1*1)=155
155 % 10 = 5
So 55865-51-5 is a valid CAS Registry Number.
55865-51-5Relevant articles and documents
6H-THIENO[2,3-E][1,2,4]TRIAZOLO[3,4-C][1,2,4]TRIAZEPINE DERIVATIVE
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Paragraph 0226-0228, (2020/05/07)
The 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives or salts thereof of the present invention have BRD4 inhibitory activity, and thus, they are useful as medicaments, in particular, as prophylaxis and/or therapeutic agents for diseases associated with BRD4.
Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A1 adenosine receptor modulation
Aurelio, Luigi,Valant, Celine,Flynn, Bernard L.,Sexton, Patrick M.,White, Jonathan M.,Christopoulos, Arthur,Scammells, Peter J.
experimental part, p. 6550 - 6559 (2010/11/17)
2-Amino-3-benzoylthiophenes (2A3BTs) have been widely reported to act as allosteric enhancers (AEs) at the A1 adenosine receptor (A 1AR). Herein we describe the synthesis of a series of 1-aminoindeno[1,2-c]thiophen-8-ones and a series of (2-aminoindeno[2,1-b] thiophen-3-yl)(phenyl)methanones as conformationally rigid analogues of the 2A3BTs. These compounds were screened using a functional assay of A 1AR-mediated phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in intact Chinese hamster ovary (CHO) cells to identify both potential agonistic effects as well as the ability to allosterically modulate the activity of the orthosteric agonist, N6-(R- phenylisopropyl)adenosine (R-PIA). All of the 1-aminoindeno[1,2-c]thiophen-8- ones (14a-c and 17a-f) proved either to be inactive or behaved as antagonists in the functional assay. However, the (2-aminoindeno[2,1-b]thiophen-3-yl)(phenyl) methanones with para-chloro substitution (compounds 25b, 25d, and 25f) did significantly augment the R-PIA response, indicating a positive allosteric effect.
Preparation of thienylmethanones as allosteric adenosine receptor modulators.
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, (2008/06/13)
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