5588-87-4Relevant articles and documents
Reactions of 1,2,4-Triazin-5(2H)-ones with Phenols and Aromatic Amines
Chupakbin, Oleg N.,Rusinov, Vladimir L.,Beresnev, Dmitri G.,Neunhoeffer
, p. 573 - 578 (1997)
1,2,4-Triazin-5(2H)-ones 1 react as well with phenols, resorinol and its dimethyl ethers, as with dimethyland diethylaniline, yielding 6-aryl-1,6-didydro-1,2,4-triazin-5(2H)-ones 2, 4-8, 12-15. Oxidation of the 1,6-dihydroadducts 2a,b gives the correspond
COMPOUNDS FOR TREATMENT OF GLIOBLASTOMA
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Paragraph 00358-00359, (2018/09/08)
The present invention relates to compounds and methods for the treatment of glioblastoma, as well as to a pharmaceutical composition comprising said compounds. More specifically the invention relates to substituted quinoline derivatives having the formula (I), (II) or (III), and a pharmaceutical composition comprising said compounds for the treatment of cancer. (Formulae (I), (II), (III))
Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties
Kawai, Megumi,BaMaung, Nwe Y.,Fidanze, Steve D.,Erickson, Scott A.,Tedrow, Jason S.,Sanders, William J.,Vasudevan, Anil,Park, Chang,Hutchins, Charles,Comess, Kenneth M.,Kalvin, Douglas,Wang, Jieyi,Zhang, Qian,Lou, Pingping,Tucker-Garcia, Lora,Bouska, Jennifer,Bell, Randy L.,Lesniewski, Richard,Henkin, Jack,Sheppard, George S.
, p. 3574 - 3577 (2007/10/03)
We have screened molecules for inhibition of MetAP2 as a novel approach toward antiangiogenesis and anticancer therapy using affinity selection/mass spectrometry (ASMS) employing MetAP2 loaded with Mn2+ as the active site metal. After a series