55899-02-0

Basic information

• Product Name: 3-methyl-N-aminopyridinium mesitylenesulfonate
• Synonyms: 3-methyl-N-aminopyridinium mesitylenesulfonate
• CAS NO: 55899-02-0
• Molecular Weight: 308.401
• Mol File: 55899-02-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-methyl-N-aminopyridinium mesitylenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-N-aminopyridinium mesitylenesulfonate(55899-02-0)
• EPA Substance Registry System: 3-methyl-N-aminopyridinium mesitylenesulfonate(55899-02-0)

Safety Data

• Hazardous Substances Data: 55899-02-0(Hazardous Substances Data)

Upstream product

• 36016-39-4 N-(tert-butoxycarbonyl)-O-(mesitylsulfonyl)hydroxylamine 
• 38202-27-6 ethyl O-(2-mesitylenesulfonyl)acetohydroxamate 
• 773-64-8 2-mesitylenesulphonyl chloride 
• 108-99-6 3-Methylpyridine 
• 36016-40-7 mesitylenesulfonylhydroxylamine 

Downstream Products

• 505087-28-5 2-(4-benzyloxy-phenyl)-8-methyl[1,2,4]triazolo[1,5-a]pyridine 
• 129254-97-3 3-methyl-4-(4-phenylbutan-2-yl)pyridine 
• 1085712-43-1 methyl 2-(4-fluorophenyl)-6-methyl-pyrazolo[1,5-a]pyridine-3-carboxylate 
• 115748-43-1 bis<α-(4-methylpyrazolo<1,5-a>pyrid-3-yl)benzyl> ether 
• 115748-42-0 phenylbis(4-methylpyrazolo<1,5-a>pyrid-3-yl)methane 
• 115748-34-0 3-(α-hydroxybenzyl)-4-methylpyrazolo<1,5-a>pyridine 
• 4931-20-8 8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine 

Relevant articles and documents

Regioselective Synthesis of Pyrazolo[1,5- a]pyridine via TEMPO-Mediated [3 + 2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds

A TEMPO-mediated [3 + 2] annulation-aromatization protocol for the preparation of pyrazolo[1,5-a]pyridines from N-aminopyridines and α,β-unsaturated compounds was developed. The procedure offered multisubstituted pyrazolo[1,5-a]pyridines in good to excellent yield with high and predictable regioselectivity. The modification of marketed drugs including Loratadine, Abiraterone, and Metochalcone, and a one-pot three-step gram scale synthesis of key intermediate for the preparation of Selpercatinib were demonstrated. Mechanism studies show that TEMPO serves both as a Lewis acid and as an oxidant.

Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors

A structure-activity relationship study for a 2-chloroanilide derivative of pyrazolo[1,5-a]pyridine revealed that increased EphB3 kinase inhibitory activity could be accomplished by retaining the 2-chloroanilide and introducing a phenyl or small electron donating substituents to the 5-position of the pyrazolo[1,5-a]pyridine. In addition, replacement of the pyrazolo[1,5-a]pyridine with imidazo[1,2-a]pyridine was well tolerated and resulted in enhanced mouse liver microsome stability. The structure-activity relationship for EphB3 inhibition of both heterocyclic series was similar. Kinase inhibitory activity was also demonstrated for representative analogs in cell culture. An analog (32, LDN-211904) was also profiled for inhibitory activity against a panel of 288 kinases and found to be quite selective for tyrosine kinases. Overall, these studies provide useful molecular probes for examining the in vitro, cellular and potentially in vivo kinase-dependent function of EphB3 receptor.

Synthesis and antifungal activity of 2-aryl-1,2,4-triazolo[1,5-a]pyridine derivatives

A series of novel antifungal triazole derivatives 2-aryl-1,2,4-triazolo[1, 5-a]pyridine 9a-m were synthesized and tested in vitro for their growth inhibitory activities against C. albicans and T. rubrum. The MIC values indicate that the activities of three compounds were superior or comparable to fluconazole against both tested fungi, worthy of further investigation of its antifungal activities.