55954-23-9Relevant articles and documents
Synthesis, Antimicrobial, and Antioxidant Screening of Aryl Acetic Acid Incorporated 1,2,4-Triazolo-1,3,4-Thiadiazole Derivatives
Kamboj, Vipan Kumar,Kapoor, Archana,Jain, Sandeep
, p. 1376 - 1382 (2019/02/20)
Some novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives were synthesized from aryl acetic acids. All the synthesized derivatives were selected for the screening of antibacterial potential against Gram-positive bacteria [Staphylococcus aureus (MTCC 3160) and Micrococcus luteus (MTCC 1538)] and Gram-negative bacteria [Escherichia coli (MTCC 1652) and Pseudomonas aeruginosa (MTCC 424)] and antifungal potential against Aspergillus niger (MTCC 8652) and Candida albicans (MTCC 227), and free radical scavenging activity through 2,2-diphenyl-2-picrylhydrazyl hydrate method. The compounds TH-4, TH-13, and TH-19 were found to be more potent antimicrobial agents compared to standard drugs. The compounds TH-3, TH-9, and TH-18 also showed significant antimicrobial activity. The compound TH-13 showed antioxidant activity with IC50 value better than the standard compound. The structures of all the synthesized compounds were confirmed by Fourier transform infrared, 1H-NMR, liquid chromatography–mass spectrometry, and CHN analyzer.
ANTI-HCMV COMPOSITIONS AND METHODS
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Page/Page column 31; 32; 49; 100, (2016/06/06)
This document relates to compounds useful as agents for preventing or treating human cytomegalovirus (HCMV) infections.
COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT
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Paragraph 0195-0196, (2016/04/26)
Compounds and compositions useful for treating disorders related to Kit are described herein.