55954-61-5

Basic information

• Product Name: Pseudohypericin
• Synonyms: PSEUDOHYPERICIN;Phenanthro[1,10,9,8-opqra]perylene-7,14-dione,1,3,4,6,8,13-hexahydroxy-10-(hydroxymethyl)-11-methyl-;1,3,4,6,8,13-Hexahydroxy-10-(hydroxymethyl)-11-methylphenanthro[1,10,9,8-opqra]perylene-7,14-dione;1,3,4,6,8,13-Hexahydroxy-10-hydroxymethyl-11-methylphenanthro[1,10,9,8-opqra]perylene-7,14-dione;PSEUDOPELLETIERINE HYDROCHLORIDE(RG)
• CAS NO: 55954-61-5
• Molecular Formula: C₃₀H₁₆O₉
• Molecular Weight: 520.44
• Product Categories: Anthraquinones, Hydroquinones and Quinones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 55954-61-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1089.1 °C at 760 mmHg
• Flash Point: 626.1 °C
• Appearance: brown/
• Density: 1.994 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 2.169
• Storage Temp.: 2-8°C
• PKA: 7.16±0.20(Predicted)
• CAS DataBase Reference: Pseudohypericin(CAS DataBase Reference)
• NIST Chemistry Reference: Pseudohypericin(55954-61-5)
• EPA Substance Registry System: Pseudohypericin(55954-61-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 22-36
• WGK Germany: 3
• Hazardous Substances Data: 55954-61-5(Hazardous Substances Data)

Usage

Description

Pseudohypericin is a naturally occurring compound found in the Hypericum perforatum plant, commonly known as St. John's wort. It is characterized by its unique chemical structure and possesses a wide range of biological activities, making it a valuable compound for various applications in the pharmaceutical and medical fields.

Uses

Used in Pharmaceutical Industry:
Pseudohypericin is used as a specific inhibitor of protein kinase C and D-β-Hydroxylase for the development of potential drug candidate molecules. Its ability to inhibit these enzymes makes it a promising candidate for the treatment of various diseases and conditions.
Used in COVID-19 Treatment Research:
Pseudohypericin is used in the determination of potential drug candidate molecules of Hypericum perforatum for COVID-19 treatment. Its unique properties and biological activities make it a valuable compound for exploring its potential in combating the virus and alleviating symptoms associated with the disease.

Enzyme inhibitor

This anti-retroviral agent (FW = 520.45 g/mol) inhibits protein kinase C with an IC50 value of 28.7 μM and dopamine b-hydroxylase with IC50 = 3 μM. Pseudohypericin is a component of St. John’s Wort (Hypericum perforatum). Target(s): dopamine b-hydroxylase; inositoltrisphosphate 3-kinase; and protein kinase C.

InChI:InChI=1/C30H16O9/c1-7-2-9(32)19-23-15(7)16-8(6-31)3-10(33)20-24(16)28-26-18(12(35)5-14(37)22(26)30(20)39)17-11(34)4-13(36)21(29(19)38)25(17)27(23)28/h2-5,31-37H,6H2,1H3