55967-94-7

Basic information

• Product Name: Pyridine, 2-oxiranyl-
• CAS NO: 55967-94-7
• Molecular Formula: C7H7NO
• Molecular Weight: 121.139
• Mol File: 55967-94-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-oxiranyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-oxiranyl-(55967-94-7)
• EPA Substance Registry System: Pyridine, 2-oxiranyl-(55967-94-7)

Safety Data

• Hazardous Substances Data: 55967-94-7(Hazardous Substances Data)

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 593-71-5 Chloroiodomethane 
• 55967-97-0 2-bromo-1-(pyridin-2-yl)ethan-1-ol 
• 1774-47-6 trimethylsulfoxonium iodide 
• 100-69-6 2-vinylpyridine 
• 2181-44-4 trimethylsulfonium methylsulfate 
• 70775-39-2 dimethylsulfoxonium methylide 
• 3086-29-1 trimethylsulfonium chloride 

Downstream Products

• 115462-38-9 2-(3-Methylphenoxy)-1-(2-pyridyl)ethanol 
• 115462-40-3 2-(benzyloxy)-1-(2-pyridyl)ethanol 
• 237081-53-7 (S)-2-(oxiran-2-yl)pyridine 
• 308366-26-9 (1R)-1-(pyridin-2-yl)ethane-1,2-diol 
• 375367-56-9 (+/-)-2-Diphenylphosphinoyl-1-(2-pyridinyl)ethanol 
• 375367-66-1 (+)-2-Phenylsulfanyl-(1S)-(2-pyridynyl)ethyl (1'S,4'R)-camphanoate 
• 375367-65-0 (-)-2-Phenylsulfanyl-(1R)-(2-pyridynyl)ethyl (1'S,4'R)-camphanoate 
• 375367-61-6 (-)-2-Diphenylphosphinoyl-(1R)-(2-pyridynyl)ethyl (1'S,4'R)-camphanoate 
• 73908-30-2 (-)-(R)-2-Pyridylethylene oxide 
• 3944-00-1 (2-pyridinyl)-1,2-ethanediol 
• 93-56-1 phenylethane 1,2-diol 

Relevant articles and documents

Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

The generation of highly unstable chloromethylmagnesium chloride in a continuous flow reactor and its reaction with aldehydes and ketones is reported. With this strategy, chlorohydrins and epoxides were synthesized within a total residence time of only 2.6 s. The outcome of the reaction can be tuned by simply using either a basic or an acidic quench. Very good to excellent isolated yields, up to 97%, have been obtained for most cases (30 examples).

Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.

DNA-based hydrolytic kinetic resolution of epoxides

DNA-bound copper(II) complexes serve as catalysts for the hydrolytic kinetic resolution of 2-pyridyloxiranes in water. Selectivity factors of up to 2.7 were achieved, indicating a chirality transfer of DNA to epoxides via a coordinated metal ion.