55984-93-5

Basic information

• Product Name: 2,5-Dicyanotoluene
• Synonyms: METHYLTEREPHTHALONITRILE 98;2,5-Dicyanotoluene;2-Methyl-1,4-benzenedicarbonitrile;Methylterephthalonitrile;2-Methylbenzene-1,4-dicarbonitrile;Methylterephthalonitrile 98%
• CAS NO: 55984-93-5
• Molecular Formula: C₉H₆N₂
• Molecular Weight: 142.16
• Product Categories: C8 to C9;Cyanides/Nitriles;Nitrogen Compounds
• Mol File: 55984-93-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 149-151 °C(lit.)
• Boiling Point: 314.995 °C at 760 mmHg
• Flash Point: 155.395 °C
• Appearance: /
• Density: 1.12
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,5-Dicyanotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dicyanotoluene(55984-93-5)
• EPA Substance Registry System: 2,5-Dicyanotoluene(55984-93-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 55984-93-5(Hazardous Substances Data)

Usage

General Description

2,5-Dicyanotoluene is a chemical compound identified by the CAS number 39310-87-1. It is also known by synonyms such as Dicarbonitrile, Benzonitrile, 2,5-dimethyl- and Toluene, 2,5-dicyano-. It is typically colorless and appears as a solid powder. 2,5-Dicyanotoluene is commonly used in the synthesis of other chemicals, including dyes and pharmaceuticals. Its properties include good thermal stability and volatility. It is essential to handle it with care as it is considered harmful if swallowed, inhaled, or comes into contact with skin.

InChI:InChI=1/C9H6N2/c1-7-4-8(5-10)2-3-9(7)6-11/h2-4H,1H3

Upstream product

• 920-68-3 heptamethyldisilazane 
• 10347-14-5 2-cyano-1,4-benzenedicarbonitrile 
• 615-59-8 1,4-dibromo-2-methylbenzene 
• 86164-70-7 2-methyl-2-phenylmalononitrile 
• 19398-61-9 2,5-dichlorotoluene 
• 151-50-8 potassium cyanide 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 117269-72-4 (3-cyano-benzyl)zinc(II) bromide 
• 544-92-3 copper(I) cyanide 
• 107-46-0 Hexamethyldisiloxane 
• 1825-62-3 ethyl trimethylsilyl ether 
• 75-76-3 tetramethylsilane 
• 623-26-7 terephthalonitrile 
• 98689-31-7 tetramethylammonium methyltriphenylborate 

Downstream Products

• 872018-09-2 2-[(2,4-dimethoxyphenyl)methyl]-1-imino-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile 
• 215454-95-8 6-(aminomethyl)isoquinolin-1-ylamine 
• 69526-90-5 2-formylterephthalic acid 
• 14186-60-8 2-Methyl-1,4-benzoldicarbonsaeure dimethylester 

Relevant articles and documents

Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation

Herein, we report a Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malononitrile (MPMN). MPMN is a bench-stable, carbon-bound electrophilic CN reagent that does not release cyanide under the reaction conditions. A variety of medicinally relevant benzonitriles can be made in good yields. Addition of NaBr to the reaction mixture allows for the use of more challenging aryl electrophiles such as aryl chlorides, tosylates, and triflates. Mechanistic investigations suggest that NaBr plays a role in facilitating oxidative addition with these substrates.

PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS

In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.

Novel trans-spanned palladium complexes as efficient catalysts in mild and amine-free cyanation of aryl bromides under air

The use of a novel trans-spanned palladium complex as an efficient and selective catalyst in the cyanation of aryl halides is described. The suggested reaction conditions are mild, exhibit good scope of substrates, and circumvent the need for an inert atmosphere and amine co-ligands.