56014-51-8

Basic information

• Product Name: 1H-Pyrrole, 1-[2-(3,4-dimethoxyphenyl)ethyl]-
• CAS NO: 56014-51-8
• Molecular Formula: C14H17NO2
• Molecular Weight: 231.294
• Mol File: 56014-51-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-[2-(3,4-dimethoxyphenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-[2-(3,4-dimethoxyphenyl)ethyl]-(56014-51-8)
• EPA Substance Registry System: 1H-Pyrrole, 1-[2-(3,4-dimethoxyphenyl)ethyl]-(56014-51-8)

Safety Data

• Hazardous Substances Data: 56014-51-8(Hazardous Substances Data)

Upstream product

• 109-97-7 pyrrole 
• 40173-90-8 3,4-dimethoxyphenethyl bromide 
• 75010-39-8 1-(3,4-dimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethane 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Downstream Products

• 194209-32-0 1-[2-(1H-pyrrol-1-yl)ethyl]benzene-1,2-diol 
• 1428317-13-8 C₂₁H₂₀INO₅ 

Relevant articles and documents

Development of Pd(OAc)2-catalyzed tandem oxidation of C[sbnd]N, C[sbnd]C, and C(sp3)–H bonds: Concise synthesis of 1-aroylisoquinoline, oxoaporphine, and 8-oxyprotoberberine alkaloids

A catalytic tandem oxidation of C[sbnd]N, C[sbnd]C, and C(sp3)–H bonds is developed. This tandem oxidation is applied to two-step total syntheses of papaveraldine and pulcheotine A. Additionally, the total synthesis of liriodenine is achieved in six steps from homopiperonyl alcohol and 2-bromophenylacetonitrile by applying this catalytic tandem oxidation. Moreover, the direct conversion of xylopinine to 8-oxypseudopalmatine in a 76% yield demonstrates the versatility of this catalytic reaction.

A simple route to new phenanthro- and phenanthroid-fused thiazoles by a PIFA-mediated (hetero)biaryl coupling reaction

An application of the PIFA-mediated [PIFA: phenyliodine(III) bis(trifluoroacetate) biaryl coupling reaction is presented and extended to the formation of heterobiaryl connections. A preliminary study of the scope and limitations of this procedure was carried out in the synthesis of phenanthroids 11 from a series of phenethyl-substituted heterocycles 10, It was observed that in some cases a competitive dimerization process took place. It was also found that the coupling step could be efficiently extended to a larger number of examples if an aromatic ring were situated fused to the 1,2-diarylethane skeleton, as in 23 and 30. The synthesis of a series of 4,5-diarylthiazoles 23a-g was therefore carried out to explore the electronic requirements and the regioselectivity of the PIFA-mediated non-phenolic coupling reaction. When the same procedure was applied to aryl-heteroarylthiazoles 30, a series of phenanthroid-fused thiazoles 31 was obtained in good overall yields. To the best of our knowledge, no oxidative aryl-heteroaryl coupling reaction of this type had previously been reported. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.