56100-69-7Relevant articles and documents
Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors
Stille, Julia K.,Tjutrins, Jevgenijs,Wang, Guanyu,Venegas, Felipe A.,Hennecker, Christopher,Rueda, Andrés M.,Sharon, Itai,Blaine, Nicole,Miron, Caitlin E.,Pinus, Sharon,Labarre, Anne,Plescia, Jessica,Burai Patrascu, Mihai,Zhang, Xiaocong,Wahba, Alexander S.,Vlaho, Danielle,Huot, Mitchell J.,Schmeing, T. Martin,Mittermaier, Anthony K.,Moitessier, Nicolas
, (2022/01/08)
Severe diseases such as the ongoing COVID-19 pandemic, as well as the previous SARS and MERS outbreaks, are the result of coronavirus infections and have demonstrated the urgent need for antiviral drugs to combat these deadly viruses. Due to its essential role in viral replication and function, 3CLpro (main coronaviruses cysteine-protease) has been identified as a promising target for the development of antiviral drugs. Previously reported SARS-CoV 3CLpro non-covalent inhibitors were used as a starting point for the development of covalent inhibitors of SARS-CoV-2 3CLpro. We report herein our efforts in the design and synthesis of submicromolar covalent inhibitors when the enzymatic activity of the viral protease was used as a screening platform.
A simple method for preparation of ZnO nanoparticles as a highly efficient nanocatalyst for N-formylation of primary and secondary amines under solvent-free condition
Alinezhad, Heshmatollah,Salehian, Fatemeh
, p. 532 - 538 (2013/07/19)
A convenient reaction between alky, aryl, and heteroalkyl amines and formic acid as a formylating agent in the presence of catalytic amount of mechanochemically synthesized zinc oxide nanoparticles under solvent-free condition for the synthesis of corresponding N-formyl derivatives is described. Copyright Taylor and Francis Group, LLC.
Cyclopeptide alkaloids. Synthesis of the ring system and its ion affinity
Lagarias,Houghten,Rapoport
, p. 8202 - 8209 (2007/10/05)
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