561068-92-6Relevant articles and documents
Studies towards the biomimetic synthesis of pyridomacrolidin
Irlapati, Nageswara Rao,Baldwin, Jack E.,Adlington, Robert M.,Pritchard, Gareth J.,Cowley, Andrew R.
, p. 4603 - 4614 (2007/10/03)
A possible biomimetic synthesis of pyridomacrolidin has been proposed and experimentally supported by carrying out a model study. Regio and stereospecific [3+2] cycloaddition of an in situ generated unusual di-tert-butylated acyl nitrone with Z-2-cyclodecenone and subsequent aromatisation was the key step in our proposed biomimetic synthesis. Finally a pyridomacrolidin analogue was prepared via Friedel-Crafts di-de-t-butylation of the cycloadduct.