561303-39-7 Usage
Molecular structure
A piperazinecarboxylic acid derivative with a phenylmethyl group, a propynyl group, and a methyl ester.
Potential pharmaceutical properties
Neuroprotective and anti-inflammatory agent
Possible applications
Treatment of neurological disorders and inflammatory diseases
Specific mechanisms of action
Under investigation
Current status
Under investigation for potential therapeutic uses
Unique chemical structure
Makes it a subject of interest in the field of medicinal chemistry and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 561303-39-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,6,1,3,0 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 561303-39:
(8*5)+(7*6)+(6*1)+(5*3)+(4*0)+(3*3)+(2*3)+(1*9)=127
127 % 10 = 7
So 561303-39-7 is a valid CAS Registry Number.
561303-39-7Relevant articles and documents
Synthesis of 2,6-bridged piperazine-3-ones by N-acyliminium ion chemistry
Veerman, Johan J. N.,Bon, Robin S.,Hue, Bui T. B.,Girones, Daniel,Rutjes, Floris P. J. T.,Van Maarseveen, Jan H.,Hiemstra, Henk
, p. 4486 - 4494 (2007/10/03)
Several 2-substituted and 2,5-disubstituted piperazine-3,6-diones were synthesized starting from readily available α-amino acids. After activation of a lactam carbonyl via introduction of a methoxycarbonyl group onto nitrogen, this carbonyl was selectively reduced. Treatment of the resulting urethane with protic acid generated the corresponding N-acyliminium ion, which was trapped by a nucleophilic C2-side chain to provide 2,6-bridged piperazine-3-ones. Several aromatic, heteroaromatic, and nonaromatic side chains were used as π-nucleophiles. In addition, the effect of the presence of a C5-methyl group on the stereochemical outcome of the cyclization was examined.
