56158-48-6 Usage
Description
N-(2-Hydroxyethyl)carbamodithioic Acid Methyl Ester is an organic compound that serves as a crucial intermediate in the chemical synthesis process. It is characterized by its unique molecular structure, which includes a carbamodithioic acid group and a hydroxyethyl group, as well as a methyl ester functional group. N-(2-Hydroxyethyl)carbaModithioic Acid Methyl Ester plays a significant role in the pharmaceutical industry due to its ability to contribute to the formation of various therapeutic agents.
Uses
Used in Pharmaceutical Industry:
N-(2-Hydroxyethyl)carbamodithioic Acid Methyl Ester is used as an intermediate in the synthesis of oxacephem antibiotics for their development and production. These antibiotics are known for their broad-spectrum antimicrobial properties, making them effective against a wide range of bacterial infections. N-(2-Hydroxyethyl)carbaModithioic Acid Methyl Ester's role in the synthesis process is essential, as it helps create the core structure of the antibiotics, which then undergo further modifications to enhance their therapeutic properties and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 56158-48-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,1,5 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 56158-48:
(7*5)+(6*6)+(5*1)+(4*5)+(3*8)+(2*4)+(1*8)=136
136 % 10 = 6
So 56158-48-6 is a valid CAS Registry Number.
56158-48-6Relevant articles and documents
α2-adrenoceptor antagonists: Synthesis, pharmacological evaluation, and molecular modeling investigation of pyridinoguanidine, pyridino-2-aminoimidazoline and their derivatives
Kelly, Brendan,McMullan, Michela,Muguruza, Carolina,Ortega, Jorge E.,Meana, J. Javier,Callado, Luis F.,Rozas, Isabel
, p. 963 - 977 (2015)
We have previously identified phenylguanidine and phenyl-2-aminoimidazoline compounds as high affinity ligands with conflicting functional activity at the α2-adrenoceptor, a G-protein-coupled receptor with relevance in several neuropsychiatric conditions. In this paper we describe the design, synthesis, and pharmacological evaluation of a new series of pyridine derivatives [para substituted 2- and 3-guanidino and 2- and 3-(2-aminoimidazolino)pyridines, disubstituted 2-guanidinopyridines and N-substituted-2-amino-1,4-dihydroquinazolines] that were found to be antagonists/inverse agonists of the α2-adrenoceptor. Furthermore, the compounds exert their effects at the α2-adrenoceptor both in vitro in human prefrontal cortex tissue and in vivo in rat brain as shown by microdialysis experiments. We also provide a docking study at the α2A- and α2C-adrenoceptor subtypes demonstrating the structural features required for high affinity binding to the receptor.
