5617-70-9Relevant articles and documents
Cyclopropylidenemethanone: A Quasi-Symmetrical Molecule
Brown, Ronald D.,Godfrey, Peter D.,Kleiboemer, Burkhard,Champion, Robert,Elmes, Patricia S.
, p. 7715 - 7718 (1984)
The structure of cyclopropylidenemethanone has been investigated via microwave spectroscopy.Analysis of the spectra of the ground and nine excited vibrational states has revealed the form of two bending potentials involving motion of the methanone group relative to the cyclopropylidene ring.The vibration perpendicular to the plane containing the ring carbon atoms has a double-minimum potential with the ground state lying just 2 cm-1 below the 29 cm-1 high central barrier.Analysis of this motion using the rigid bender method shows that the two potential minima lie 17.5 deg away from the ring plane.The proximity of the ground state to the top of the barrier leads to the designation of the molecule as quasi-symmetric, being close to C2ν, despite its less symmetric Cs equilibrium structure.The vibration in the plane of the ring has a near harmonic potential, with a fundamental of 154 cm-1.Analysis of the Stark effect indicates a dipole moment of 2.60(1) D.
Preparation method and application of compound containing zinc-bound and quinoline skeleton
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Paragraph 0139-0142, (2021/11/10)
The invention relates to the field of pharmaceutical chemistry, in particular to a novel zinc-containing binding group-containing quinoline compound. A geometric isomer, a pharmaceutically acceptable salt, solvate or prodrug thereof, a preparation method and thereof, and a pharmaceutical composition containing the compound. The invention also relates to an application of the compound in preparation of drugs for treating and/or preventing diseases mediated by c-Met tyrosine kinase and HDAC. The quinoline compounds, geometric isomers and pharmaceutically acceptable salts, solvates and prodrugs thereof are shown in the specification, and R. 1 , m, Q, X, As described in the claims and the description.
An efficient method for the synthesis of 2′,3′-nonsubstituted cycloalkane-1,3-dione-2-spirocyclopropanes using (2-bromoethyl)-diphenylsulfonium trifluoromethanesulfonate
Nambu, Hisanori,Ono, Naoki,Hirota, Wataru,Fukumoto, Masahiro,Yakura, Takayuki
, p. 1763 - 1768 (2016/12/09)
An efficient and practical synthesis of 2′,3′-nonsubstituted cyclohexane-1,3-dione-2-spirocyclopropanes using a sulfonium salt was achieved. The reaction of 1,3-cyclohexanediones and (2-bromoethyl)diphenylsulfonium trifluoromethanesulfonate with powdered K2CO3 in EtOAc at room temperature (r.t.) provided the corresponding spirocyclopropanes in high yields. The synthetic method was also applied to 1,3-cyclopentanedione, 1,3-cycloheptanedione, 1,3-indanedione, acyclic 1,3-diones, ethyl acetoacetate, and Meldrum's acid.
