56173-18-3

Basic information

• Product Name: ACETONE PHTHALAZIN-1-YL-HYDRAZONE
• Synonyms: ACETONE PHTHALAZIN-1-YL-HYDRAZONE;acetone,1-phthlazinylhydrazone;HydralazineAcetonide,HydralazineAcetoneHydrazone;Hydralazine acetone hydrazone;Acetone Hydralazine Hydrazone;1(2H)-Phthalazinone (1-Methylethylidene)hydrazone;HAH;Hydralazine Acetone Azine
• CAS NO: 56173-18-3
• Molecular Formula: C11H12N4
• Molecular Weight: 200.23978
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 56173-18-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 99-102°C
• Boiling Point: 327.97°C (rough estimate)
• Flash Point: 205.1°C
• Appearance: /
• Density: 1.2007 (rough estimate)
• Vapor Pressure: 4.08E-07mmHg at 25°C
• Refractive Index: 1.4260 (estimate)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: ACETONE PHTHALAZIN-1-YL-HYDRAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: ACETONE PHTHALAZIN-1-YL-HYDRAZONE(56173-18-3)
• EPA Substance Registry System: ACETONE PHTHALAZIN-1-YL-HYDRAZONE(56173-18-3)

Safety Data

• Hazardous Substances Data: 56173-18-3(Hazardous Substances Data)

Usage

Chemical Properties

Dark Yellow Solid

Uses

Different sources of media describe the Uses of 56173-18-3 differently. You can refer to the following data:
1. A Hydralazine (HP) (H716531) metabolite
2. A major metabolite of Hydralazine (H716531).

InChI:InChI=1/C11H12N4/c1-8(2)13-15-11-10-6-4-3-5-9(10)7-12-14-11/h3-7H,1-2H3,(H,14,15)

Upstream product

• 304-20-1 hydralazine hydrochloride 
• 67-64-1 acetone 

Downstream Products

• 67536-13-4 hydralazine pyruvic acid hydrazone 

Relevant articles and documents

Interactions between drug substances and excipients. 1. Fluorescence and HPLC studies of triazolophthalazine derivatives from hydralazin hydrochloride and starch

The strength of hydralazine hydrochloride (I) 10 mg tablets, containing starch as an excipient, decreases significantly with time. An investigation to determine the basis for the drop in strength showed that starch exposed to the drug exhibited fluorescence at 414 nm. As model compounds IIIa and V, which contain a triazolophthalazinyl moiety, also fluoresce at about 414 nm, it is proposed that the emission is due to a triazolophthalazine derivative (IIIc) resulting from hydralazine hydrochloride and starch. Degradation of IIIc generates s-triazolo[3;4-a]phthalazine (IIIb), and a small amount of IIIb is detected in aged tablets. IIIc in aged tablets can be converted to IIIb by acid-catalyzed hydrolysis. The quantity of IIIb determined by HPLC amounts to most of the "missing" hydralazine hydrochloride. The reaction between hydralazine hydrochloride and starch is believed to cause the unexpected drop in the strength of hydralazine hydrochloride tablets.