56220-55-4

Basic information

• Product Name: 5-amino-1-(3-deoxypentofuranosyl)-1H-imidazole-4-carboxamide
• CAS NO: 56220-55-4
• Molecular Formula: C₉H₁₄N₄O₄
• Molecular Weight: 242.2319
• Mol File: 56220-55-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 675.2°C at 760 mmHg
• Flash Point: 362.1°C
• Density: 1.89g/cm³
• Vapor Pressure: 3.76E-19mmHg at 25°C
• Refractive Index: 1.78
• CAS DataBase Reference: 5-amino-1-(3-deoxypentofuranosyl)-1H-imidazole-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-1-(3-deoxypentofuranosyl)-1H-imidazole-4-carboxamide(56220-55-4)
• EPA Substance Registry System: 5-amino-1-(3-deoxypentofuranosyl)-1H-imidazole-4-carboxamide(56220-55-4)

Safety Data

• Hazardous Substances Data: 56220-55-4(Hazardous Substances Data)

Upstream product

• 13146-72-0 3′-deoxyinosine 

Relevant articles and documents

Nucleosides and nucleotides. 143. Synthesis of 5-amino-4- imidazolecarboxamide (AICA) deoxyribosides from deoxyinosines and their conversion into 3-deazapurine derivatives

An efficient and large scale chemical synthesis of 5-aminoimidazole-4- carboxamide (AICA) 2'-deoxyriboside (5a) and its 3'-deoxyriboside 5b is described. Treatment of 3',5'-di-O-acetyl-N1-triphenylmethyl-2'-deoxyinosine (3a) with 5N NaOH in EtOH, followed by anhydrous trifluoroacetic acid gave 5a in 59% yield from 2'-deoxyinosine (1a). AICA 3'-deoxyriboside (5b) was also obtained in a similar manner as for 5a in 73% yield from 3'-deoxyinosine (1b). Conversion of these AICA derivatives (5a, b) into 3-deazapurine derivatives (9a, b, 15a, b, 20a, b) is also described.