56236-82-9

Basic information

• Product Name: Benzonitrile, 4-[(methylamino)sulfonyl]-
• Synonyms: p-(Methylsulfamoyl)-benzonitril;N-methyl-4-cyanobenzenesulfonamide;4-Cyan-benzolsulfonsaeure-methylamid;4-cyano-N-methyl-benzenesulfonamide;4-CYANO-N-METHYLBENZENESULFONAMIDE
• CAS NO: 56236-82-9
• Molecular Formula: C8H8N2O2S
• Molecular Weight: 196.23
• Mol File: 56236-82-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-[(methylamino)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-[(methylamino)sulfonyl]-(56236-82-9)
• EPA Substance Registry System: Benzonitrile, 4-[(methylamino)sulfonyl]-(56236-82-9)

Safety Data

• Hazardous Substances Data: 56236-82-9(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 3119-02-6 4-cyanobenzenesulfonamide 
• 74-88-4 methyl iodide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 49584-26-1 p-cyanobenzenesulfonyl chloride 
• 143-33-9 sodium cyanide 
• 74-89-5 methylamine 
• 623-00-7 4-bromobenzenecarbonitrile 
• 150993-53-6 4-(benzylsulfanyl)benzonitrile 

Downstream Products

• 101252-53-3 4-(aminomethyl)-N-methylbenzenesulfonamide 
• 63877-94-1 4-cyano-N,N-dimethylbenzenesulfonamide 
• 117795-62-7 N-[2-(3-chlorophenyl)-2,3-epoxypropyl]-4-cyano-N-methylbenzenesulfonamide 
• 10252-63-8 4-methylsulfamoyl-benzoic acid 

Relevant articles and documents

Copper-catalyzed oxidative methylation of sulfonamides by dicumyl peroxide

A novel and facile copper-catalyzed methylation of sulfonamides was herein demonstrated. The practical transformation took place readily under the oxidative conditions, and N-methyl amides (23 examples) were successfully furnished in high efficiency (up to 90% yields). Dicumyl peroxide was considered to act not only as the oxidant in the system, but also methyl donor for the methylation protocol.

FUNGICIDAL OXADIAZOLES

Disclosed are compounds of Formula I, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein R1, Z1, R2, Z2, J, s and f are as defined in the disclosure. Also disclosed are co

ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to a compound suitable for use as a kinase inhibitor according to general formula (I) [compound (C), herein after], or the N- oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof, formula (I) wherein A, R1, R2, R3, R3', R4, R4', X, Y, Z, T are as defined in the claims. The invention further relates to an in vitro method of inhibiting protein kinase activity which comprises contacting a protein kinase with a compound of formula (I), or the N-oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof. The invention further relates to the compounds of formula (I) per se, as well as to their use as a medicament, and for use or in a method of treatment of a disease mediated by a protein kinase selected from cancer, inflammatory disorders, cardiovascular diseases, viral induced diseases, circulatory diseases, fibro-proliferative diseases and pain sensitization disorders.