5624-35-1

Basic information

• Product Name: NICOTINAMIDE GUANINE DINUCLEOTIDE SODIUM SALT
• Synonyms: NICOTINAMIDE GUANINE DINUCLEOTIDE SODIUM SALT;nicotinamide guanine dinucleotide*sodium;nicotinamide guanine dinucleotide
• CAS NO: 5624-35-1
• Molecular Formula: C21H27N7O15P2
• Molecular Weight: 679.42
• Product Categories: NAD and Analogs;Biochemicals and Reagents;Nucleosides, Nucleotides, Oligonucleotides
• Mol File: 5624-35-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: NICOTINAMIDE GUANINE DINUCLEOTIDE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: NICOTINAMIDE GUANINE DINUCLEOTIDE SODIUM SALT(5624-35-1)
• EPA Substance Registry System: NICOTINAMIDE GUANINE DINUCLEOTIDE SODIUM SALT(5624-35-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36
• WGK Germany: 3
• Hazardous Substances Data: 5624-35-1(Hazardous Substances Data)

Usage

Description

Nicotinamide guanine dinucleotide sodium salt, also known as NAD+ sodium salt, is a coenzyme derived from the vitamin niacin. It plays a crucial role in various cellular redox reactions and is involved in the transfer of chemical energy within cells. NAD+ sodium salt is essential for the proper functioning of numerous metabolic pathways, including glycolysis, the citric acid cycle, and the electron transport chain.

Uses

Used in Enzyme Activity Measurement:
Nicotinamide guanine dinucleotide sodium salt is used as a substrate for measuring the cyclase activity of the enzyme cluster of differentiation 38 (CD38). It is crucial in determining the efficiency and functionality of CD38, which is involved in various cellular processes, including calcium mobilization, cell signaling, and immune response regulation.
Used in Fluorometric Determination:
NAD+ sodium salt is also used as a substrate to fluorometrically determine the activity of CD38/ADP-ribose (ADPR). This application aids in understanding the role of CD38 in cellular processes and its potential involvement in various diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases.

Biochem/physiol Actions

Nicotinamide guanine dinucleotide sodium salt is used to determine the activity of proteins that generate cyclic-ADP-ribose (cADPR) in the ADP-ribosyl cyclase family.

InChI:InChI=1/C21H27N7O15P2/c22-16(33)8-2-1-3-27(4-8)19-14(31)12(29)9(41-19)5-39-44(35,36)43-45(37,38)40-6-10-13(30)15(32)20(42-10)28-7-24-11-17(28)25-21(23)26-18(11)34/h1-4,7,9-10,12-15,19-20,29-32H,5-6H2,(H6-,22,23,25,26,33,34,35,36,37,38)/p+1