56279-34-6Relevant articles and documents
An efficient and enantioselective approach to 2,5-disubstituted dihydropyrones
Fu, Zhengyan,Gao, Bo,Yu, Zhipeng,Yu, Lan,Huang, Yaozhong,Feng, Xiaoming,Zhang, Guolin
, p. 1772 - 1775 (2004)
A highly efficient method for the formation of optically active 2,5-disubstituted dihydropyrones using catalytic enantioselective hetero-Diels-Alder reaction of (E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1, 3-butadiene with aldehydes is presented. In the presence of 5 mol% chiral titanium(IV) complex, this catalytic reaction proceeded smoothly to afford corresponding dihydropyrones in moderate to excellent yields with high enantioselectivities (up to 99% ee).
Two approaches to the aromatic core of the aminonaphthoquinone antibiotics
Nawrat, Christopher C.,Palmer, Leoni I.,Blake, Alexander J.,Moody, Christopher J.
, p. 5587 - 5603 (2013/07/26)
Two complementary approaches are presented for the synthesis of the quinone chromophores of the naphthoquinone ansamycins and related natural products. The first involves the use of an improved protocol for the manganese(III) acetate mediated cyclization of 5-aryl-1,3-dicarbonyl compounds to β-naphthols, leading to the simple, scalable preparation of building blocks suitable for the synthesis of naturally occurring aminonaphthoquinones. The second approach involves the Diels-Alder reaction of a series of new, ester-containing Danishefsky-type dienes with N-protected aminobenzoquinones to allow more expeditious access to similar intermediates.
The efficient and regioselective synthesis of the naphthoquinone core of streptovaricin U
Miyashita, Masaaki,Yamasaki, Takahiro,Shiratani, Tomonori,Hatakeyama, Susumi,Miyazawa, Masahiro,Irie, Hiroshi
, p. 1787 - 1788 (2007/10/03)
The efficient and regioselective synthesis of the naphthoquinone core of streptovaricin U 1 via the Diels-Alder reaction of 1-methoxy-2-methyl-3-trimethylsilyloxybuta-1,3-diene 5 with the 2,6-dibromo-3-methyl-1,4-benzoquinone 6 is described.
